Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.81 |
| ▸ | TP53 | P04637 | 1/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.81 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.81 |
| ▸ | BLM | P54132 | 1/20 | 0.81 |
| ▸ | CASP7 | P55210 | 1/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | RXRA | P19793 | 2/20 | 0.57 |
| ▸ | RXRB | P28702 | 2/20 | 0.57 |
| ▸ | RXRG | P48443 | 1/20 | 0.57 |
| ▸ | XDH | P47989 | 1/20 | 0.54 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918994 | 1.00 | MAPT (0.81) | MAPTSMN1; SMN2TP53CYP3A4ALOX15 | |
| SCHEMBL2307737 | 0.89 | MAPT (1.00) | MAPTSMN1; SMN2TP53CYP3A4ALOX15 | |
| SCHEMBL2307743 | 0.89 | MAPT (1.00) | MAPTSMN1; SMN2TP53CYP3A4ALOX15 | |
| SCHEMBL8459972 | 0.86 | MAPT (0.78) | MAPTSMN1; SMN2TP53CYP3A4ALOX15 | |
| SCHEMBL8459973 | 0.86 | MAPT (0.78) | MAPTSMN1; SMN2TP53CYP3A4ALOX15 | |
| SCHEMBL14918792 | 0.84 | TDP1 (0.63) | MAPTSMN1; SMN2TP53CYP3A4ALOX15 | |
| SCHEMBL14918794 | 0.84 | TDP1 (0.63) | MAPTSMN1; SMN2TP53CYP3A4ALOX15 | |
| SCHEMBL14918605 | 0.84 | MAPT (0.59) | MAPTSMN1; SMN2TP53CYP3A4ALOX15 | |
| SCHEMBL14918608 | 0.84 | MAPT (0.59) | MAPTSMN1; SMN2TP53CYP3A4ALOX15 | |
| SCHEMBL17832979 | 0.83 | MAPT (0.87) | MAPTSMN1; SMN2TP53CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140275049-A1 | SUBSTITUTED PYRAZOLE ANALOGS As RAR ANTAGONISTS | ELI LILLY AND COMPANY | 2014-09-18 | — | — | US | disclosed |
| WO-2013066640-A1 | SUBSTITUTED PYRAZOLE ANALOGUES AS RAR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2013-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275049-A1 | SUBSTITUTED PYRAZOLE ANALOGS As RAR ANTAGONISTS | RARB, RARA, RARG | MAPT 4647/4885SMN1; SMN2 3574/4885TP53 534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.