Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 10/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 5/20 | 0.45 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.45 |
| ▸ | PSAT1 | Q9Y617 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CTSH | P09668 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11969895 | 1.00 | MME (0.52) | MMEMEN1NPC1KMT2AACE | |
| SCHEMBL18626432 | 0.90 | MME (0.47) | MMEMEN1NPC1KMT2AACE | |
| SCHEMBL16930437 | 0.88 | MME (0.48) | MMEMEN1NPC1KMT2AACE | |
| SCHEMBL16930474 | 0.88 | MME (0.46) | MMEMEN1NPC1KMT2AACE | |
| SCHEMBL11969564 | 0.87 | MME (0.69) | MMEACEPPARGEPHX2GPR88 | |
| SCHEMBL16939264 | 0.87 | MME (0.69) | MMEACEPPARGEPHX2GPR88 | |
| SCHEMBL14890510 | 0.87 | MME (0.48) | MMEMEN1NPC1KMT2APPARG | |
| SCHEMBL18597892 | 0.87 | MME (0.48) | MMEMEN1NPC1KMT2APPARG | |
| SCHEMBL16930426 | 0.86 | MME (0.59) | MMEMEN1NPC1KMT2AACE | |
| SCHEMBL18874737 | 0.85 | MME (0.49) | MMEMEN1NPC1KMT2ASRR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773335-A1 | NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013067163-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2013-05-10 | — | — | WO | disclosed |