Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 11/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14890510 | 1.00 | MME (0.48) | MMEPPARGPPARAALDH1A1MAPT | |
| SCHEMBL18386378 | 0.91 | MME (0.43) | MMEPPARGPPARAALDH1A1MAPT | |
| SCHEMBL18597988 | 0.87 | PPARG (0.46) | MMEPPARGPPARAALDH1A1MAPT | |
| SCHEMBL14919221 | 0.87 | MME (0.52) | MMEPPARGPPARAGPR88MEN1 | |
| SCHEMBL11969895 | 0.87 | MME (0.52) | MMEPPARGPPARAGPR88MEN1 | |
| SCHEMBL16939261 | 0.86 | MME (0.55) | MME | |
| SCHEMBL16939264 | 0.82 | MME (0.69) | MMEPPARGGPR88CA12CA1 | |
| SCHEMBL11969564 | 0.82 | MME (0.69) | MMEPPARGGPR88CA12CA1 | |
| SCHEMBL20371160 | 0.82 | MME (0.51) | MMEPPARGPPARANPSR1 | |
| SCHEMBL20376371 | 0.79 | MME (0.42) | MMEPPARGPPARACA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773335-B1 | OXALIC ACID AMIDES AS NEPRILYSIN INHIBITORS, PHARMACEUTICAL COMPOSITION THEREOF AND PREPARATION THEREOF | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-03-08 | — | — | EP | disclosed |