Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 20/20 | 0.68 |
| ▸ | ACE | P12821 | 15/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14891853 | 1.00 | MME (0.68) | MMEACE | |
| SCHEMBL14890559 | 0.91 | MME (0.61) | MMEACE | |
| SCHEMBL14890537 | 0.89 | MME (0.73) | MMEACE | |
| SCHEMBL14891285 | 0.89 | MME (0.71) | MMEACE | |
| SCHEMBL18598045 | 0.89 | MME (0.71) | MMEACE | |
| SCHEMBL14890847 | 0.88 | MME (0.74) | MMEACE | |
| SCHEMBL14890644 | 0.88 | MME (0.69) | MMEACE | |
| SCHEMBL14890631 | 0.82 | MME (0.60) | MMEACE | |
| SCHEMBL18597868 | 0.81 | MME (1.00) | MMEACE | |
| SCHEMBL14890447 | 0.81 | MME (1.00) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773335-A1 | NEPRILYSIN INHIBITORS | Theravance, Inc. (US) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013067163-A1 | NEPRILYSIN INHIBITORS | THERAVANCE, INC. (US) | 2013-05-10 | — | — | WO | disclosed |