Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 19/20 | 0.71 |
| ▸ | ACE | P12821 | 15/20 | 0.71 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14891285 | 1.00 | MME (0.71) | MMEACEMMEL1 | |
| SCHEMBL14890644 | 0.90 | MME (0.69) | MMEACE | |
| SCHEMBL14891853 | 0.89 | MME (0.68) | MMEACE | |
| SCHEMBL14919304 | 0.89 | MME (0.68) | MMEACE | |
| SCHEMBL18597969 | 0.88 | MME (0.75) | MMEACEMMEL1 | |
| SCHEMBL14890590 | 0.88 | MME (0.75) | MMEACEMMEL1 | |
| SCHEMBL14890832 | 0.87 | MME (0.75) | MMEACEMMEL1 | |
| SCHEMBL18597851 | 0.87 | MME (0.75) | MMEACEMMEL1 | |
| SCHEMBL14890925 | 0.85 | MME (0.59) | MMEACEMMEL1 | |
| SCHEMBL18597834 | 0.85 | MME (0.59) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773335-B1 | OXALIC ACID AMIDES AS NEPRILYSIN INHIBITORS, PHARMACEUTICAL COMPOSITION THEREOF AND PREPARATION THEREOF | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-03-08 | — | — | EP | disclosed |