Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | HTR7 | P34969 | 6/20 | 0.58 |
| ▸ | HTR1D | P28221 | 3/20 | 0.58 |
| ▸ | HTR2B | P41595 | 3/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | HTR1B | P28222 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17014218 | 0.92 | MEN1 (0.58) | MEN1KMT2AHTR7HTR1DHTR2B | |
| SCHEMBL8564336 | 0.85 | MEN1 (0.83) | MEN1KMT2ACNR1EPHX2TSHR | |
| SCHEMBL13599035 | 0.85 | MEN1 (0.64) | MEN1KMT2ACNR1EPHX2TSHR | |
| SCHEMBL2962589 | 0.84 | MEN1 (0.62) | MEN1KMT2ACNR1EPHX2TSHR | |
| SCHEMBL3977265 | 0.82 | MEN1 (0.64) | MEN1KMT2AHTR2AHTR2CCNR1 | |
| SCHEMBL31212414 | 0.82 | MEN1 (0.64) | MEN1KMT2ACNR1EPHX2TSHR | |
| SCHEMBL7216688 | 0.82 | KMT2A (0.97) | MEN1KMT2AHTR2BHTR1ACNR1 | |
| SCHEMBL17007472 | 0.81 | MEN1 (0.71) | MEN1KMT2ACNR1EPHX2TSHR | |
| SCHEMBL13598934 | 0.81 | HDAC3 (0.68) | MEN1KMT2AHTR2AHTR2CCNR1 | |
| SCHEMBL1063351 | 0.81 | KMT2A (1.00) | MEN1KMT2ACNR1EPHX2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066469-A2 | KINASE INHIBITORS CAPABLE OF INCREASING THE SENSITIVITY OF BACTERIAL PATHOGENS TO B-LACTAM ANTIBIOTICS | SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2013-05-10 | — | — | WO | disclosed |