Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.83 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | CNR1 | P21554 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | TGM2 | P21980 | 1/20 | 0.56 |
| ▸ | GPR183 | P32249 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 2/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216688 | 0.93 | KMT2A (0.97) | MEN1KMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL6568319 | 0.92 | MEN1 (0.71) | MEN1KMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL1063351 | 0.91 | KMT2A (1.00) | MEN1KMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL2952847 | 0.89 | MAPT (0.71) | MEN1KMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL20021983 | 0.88 | KMT2A (0.71) | MEN1KMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL2960623 | 0.88 | MEN1 (0.71) | MEN1KMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL8898704 | 0.87 | CNR1 (0.67) | MEN1KMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL2962437 | 0.86 | KMT2A (0.64) | MEN1KMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL2953438 | 0.86 | CNR1 (0.65) | MEN1KMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL14919477 | 0.85 | MEN1 (0.68) | MEN1KMT2ATSHRMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644182-B1 | Cyclohexane derivatives useful as potassium channel openers | EISAI CO LTD (JP) | 1998-05-13 | — | — | EP | disclosed |
| US-5605907-A | USEFUL AS A PREVENTIVE AND THERAPEUTIC AGENT FOR DISEASES AGAINST WHICH A POTASSIUM CHANNEL OPENING ACTION IS EFFICACIOUS | EISAI CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5478839-A | Potassium channel modulator, bronchodilator agent, muscle relaxants, vasodilator | EISAI CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| EP-0644182-A1 | Cyclohexane derivatives useful as potassium channel openers | Eisai Co., Ltd. (JP) | 1995-03-22 | — | — | EP | disclosed |