Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.78 |
| ▸ | HPGD | P15428 | 6/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919711 | 0.88 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL14919776 | 0.87 | ALDH1A1 (0.78) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL14919793 | 0.86 | ALDH1A1 (0.91) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL7399750 | 0.85 | ALDH1A1 (0.71) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL14919764 | 0.84 | ALDH1A1 (0.73) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL14919467 | 0.84 | ALDH1A1 (0.76) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL14919775 | 0.82 | ALDH1A1 (0.82) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL1332026 | 0.82 | KMT2A (0.62) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL14919530 | 0.81 | ALDH1A1 (0.63) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL14919481 | 0.80 | POLB (0.68) | ALDH1A1HPGDKDM4EHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066469-A2 | KINASE INHIBITORS CAPABLE OF INCREASING THE SENSITIVITY OF BACTERIAL PATHOGENS TO B-LACTAM ANTIBIOTICS | SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2013-05-10 | — | — | WO | disclosed |