Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 6/20 | 0.60 |
| ▸ | NMT2 | O60551 | 1/20 | 0.52 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14921785 | 0.87 | NMT1 (0.51) | NMT1 | |
| SCHEMBL14921784 | 0.87 | NMT1 (0.51) | NMT1 | |
| SCHEMBL14920309 | 0.87 | NMT1 (0.51) | NMT1 | |
| SCHEMBL4099146 | 0.86 | CCR5 (0.48) | NMT1CCR5 | |
| SCHEMBL4110254 | 0.85 | NMT1 (0.45) | NMT1NMT2CCR5PDE4APDE4B | |
| SCHEMBL20475198 | 0.85 | NMT1 (0.45) | NMT1NMT2CCR5CYP1A2CYP3A4 | |
| SCHEMBL20475148 | 0.81 | NMT1 (0.57) | NMT1NMT2CCR5RECQLPDE4A | |
| SCHEMBL26131609 | 0.81 | KDM1A (0.48) | NMT1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL31412605 | 0.80 | PDE4B (0.59) | NMT1NMT2PDE4APDE4BPDE4C | |
| SCHEMBL4011915 | 0.80 | PDE4B (0.59) | NMT1NMT2PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773637-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | Xenon Pharmaceuticals Inc. (CA) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013064983-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2013-05-10 | — | — | WO | disclosed |