Gambogic Acid

Gambogic Acid

SCHEMBL149213

CC(C)=CCCC1(C)C=Cc2c(O)c3c(c(CC=C(C)C)c2O1)O[C@]12C(=C[C@@H]4CC1C(C)(C)OC2(C/C=C(\C)C(=O)O)C4=O)C3=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 6/20 1.00
MAPT P10636 6/20 1.00
MAPK1 P28482 6/20 1.00
HSD17B10 Q99714 6/20 1.00
PTPN1 P18031 6/20 1.00
CYP3A4 P08684 5/20 1.00
SMN1; SMN2 Q16637 5/20 1.00
ALOX15 P16050 5/20 1.00
HPGD P15428 3/20 1.00
BLM P54132 3/20 1.00
KDM4E B2RXH2 3/20 1.00
IKBKB O14920 3/20 1.00
HSP90AA1 P07900 1/20 1.00
HSP90AB1 P08238 1/20 1.00
BCL2 P10415 1/20 1.00
TXN P10599 1/20 1.00
BCL2L1 Q07817 1/20 1.00
MCL1 Q07820 1/20 1.00
BCL2A1 Q16548 1/20 1.00
SPTSSB Q8NFR3 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gambogic Acid SCHEMBL12751296 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL13613351 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL13685812 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL12025387 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL12025441 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL12045553 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL24089082 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL12026374 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL16160279 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1
Gambogic Acid SCHEMBL12045554 1.00 TP53 (1.00) TP53MAPTMAPK1HSD17B10PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2679 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121489900-B Preparation and application of gambogic acid preparation for targeting malignant tumor ANHUI UNIVERSITY OF CHINESE MEDICINE (CN) 2026-05-26 CN claimed
CN-122075731-A Gambogic acid kidney delivery system based on beta-lactoglobulin reabsorption mediation and synthesis method and application thereof 2026-05-26 CN claimed
US-20260096569-A1 EDIBLE COATING WITH ANTIMICROBIAL PROPERTIES APEEL TECH INC (US) 2026-04-09 US claimed
EP-4714447-A1 DRUG COMBINATIONS OF BCL-XL INHIBITORS FOR TREATMENT OF CANCER Stichting Amsterdam UMC (NL) 2026-03-25 EP claimed
US-12576029-B2 Noncompetitive receptor-targeted vaccine delivery to plasmacytoid dendritic cells WASHINGTON UNIVERSITY (US) 2026-03-17 US claimed
EP-4678750-A1 REPLICON DNA, CLONING VECTOR, SCREENING KIT, SCREENING METHOD, ANTI-NOBECOVIRUS AGENT, BETA-CORONAVIRUS PROLIFERATION INHIBITOR, PAN BETA-CORONAVIRUS INHIBITOR, VIRUS PROLIFERATION INHIBITOR, HEPATITIS C VIRUS PROLIFERATION INHIBITOR, AND METHOD FOR SCREENING THERAPEUTIC AGENT FOR VIRAL INFECTIOUS DISEASE Kagoshima University (JP) 2026-01-14 EP claimed
US-20260007728-A1 COMBINATION THERAPIES INVOLVING L-ASPARAGINASE U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE 2026-01-08 US claimed
US-20250372756-A1 COATING, BATTERY, AND ELECTRICITY-CONSUMPTION DEVICE XIAMEN HITHIUM ENERGY STORAGE TECH CO LTD (CN) 2025-12-04 US claimed
EP-4657565-A2 COATING, BATTERY, AND ELECTRICITY-CONSUMPTION DEVICE Xiamen Hithium Energy Storage Technology Co., Ltd. (CN) 2025-12-03 EP claimed
US-20250339399-A1 SUPRAMOLECULAR SELF-ASSEMBLY SYSTEM BEIJING CREATRON INSTITUTE OF PHARMACEUTICAL RES CO LTD (CN) 2025-11-06 US claimed
US-6613762-B2 Synergystic mixtures comprising prodrugs, 9,10-dihydrogambogic acid and antibodies, cell growth factors or cytokines, used as anticarcinogenic agents CYTOVIA, INC. 2003-09-02 US claimed
US-20030078292-A1 Gambogic acid, analogs and derivatives as activators of caspases and inducers of apoptosis CYTOVIA, INC. 2003-04-24 US claimed
CN-1390839-A Composition of garcinolic acid compounds, its preparing process and medical composition using it as active component BODA INST OF MEDICAL MATERIALS (CN) 2003-01-15 CN claimed
US-6462041-B1 ACTIVATORS OF CASPASE CASCADE; TREATING, PREVENTING OR AMELIORATING NEOPLASIA AND CANCER CYTOVIA, INC. 2002-10-08 US claimed
EP-1180991-A2 GAMBOGIC ACID, ANALOGS AND DERIVATIVES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS Cytovia, Inc. (US) 2002-02-27 EP claimed
EP-1151295-A1 METHODS OF IDENTIFYING THERAPEUTICALLY EFFECTIVE ANTINEOPLASTIC AGENTS WITH CULTURED CELLS HAVING INTACT CELL MEMBRANES AND CORRESPONDING PRODUCTS Cytovia, Inc. (US) 2001-11-07 EP claimed
CN-1309125-A Composition of gambogic acid compounds with anticancer activity and its preparing process CHINESE PHARMACY UNIV (CN) 2001-08-22 CN claimed
WO-2000045165-A1 METHODS OF IDENTIFYING THERAPEUTICALLY EFFECTIVE ANTINEOPLASTIC AGENTS WITH CULTURED CELLS HAVING INTACT CELL MEMBRANES AND CORRESPONDING PRODUCTS CYTOVIA, INC. (US) 2000-08-03 WO claimed
WO-2000044216-A1 GAMBOGIC ACID, ANALOGS AND DERIVATIVES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS CYTOVIA, INC. (US) 2000-08-03 WO claimed
WO-2000044216-A2 GAMBOGIC ACID, ANALOGS AND DERIVATIVES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS CYTOVIA INC (US) 2000-08-03 WO claimed