Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 6/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 1.00 |
| ▸ | PTPN1 | P18031 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | BLM | P54132 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | IKBKB | O14920 | 3/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 1.00 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 1.00 |
| ▸ | BCL2 | P10415 | 1/20 | 1.00 |
| ▸ | TXN | P10599 | 1/20 | 1.00 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 1.00 |
| ▸ | MCL1 | Q07820 | 1/20 | 1.00 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 1.00 |
| ▸ | SPTSSB | Q8NFR3 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gambogic Acid SCHEMBL12751296 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL13613351 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL13685812 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL12025387 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL12045553 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL24089082 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL12026374 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL16160279 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL12045554 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL13685811 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160338991-A1 | NOVEL COMPOUND OBTAINED FROM GAMBOGE RESIN, AND MEDICAL USES OF THE SAME | TAIWAN SUNPAN BIOTECHNOLOGY DEVELOPMENT CO., LTD | 2016-11-24 | — | — | US | disclosed |
| US-9498463-B2 | Compound obtained from gamboge resin, and medical uses of the same | TAIWAN SUNPAN BIOTECHNOLOGY DEVELOPMENT CO., LTD. (TW) | 2016-11-22 | — | — | US | disclosed |
| US-20160089357-A1 | USE OF FRACTIONATED PRODUCTS OF GAMBOGE RESIN IN THE TREATMENT OF CANCER, PAIN, AND INFLAMMATION | TAIWAN SUNPAN BIOTECHNOLOGY DEVELOPMENT CO., LTD. (TW) | 2016-03-31 | — | — | US | disclosed |
| US-20110306658-A1 | Novel compound obtained from gamboge resin, and medical uses of the same | Taiwan Sunpan Biotechnology Development Co, Ltd. (TW) | 2011-12-15 | — | — | US | disclosed |
| US-20110305784-A1 | Fractionated products obtained from gamboge resin, and medical uses of the same | Taiwan Sunpan Biotechnology Development Co, Ltd. (TW) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160089357-A1 | USE OF FRACTIONATED PRODUCTS OF GAMBOGE RESIN IN THE TREATMENT OF CANCER, PAIN, AND INFLAMMATION | PTGES, PTGS1, GYPA | TP53 2080/4885MAPT 4615/4885MAPK1 2820/4885 |
| US-20160338991-A1 | NOVEL COMPOUND OBTAINED FROM GAMBOGE RESIN, AND MEDICAL USES OF THE SAME | PGGT1B, RXRG, PTGIS | TP53 2012/4885MAPT 4736/4885MAPK1 3234/4885 |
| US-20110305784-A1 | Fractionated products obtained from gamboge resin, and medical uses of the same | PTGES, GYPA, PTGIS | TP53 2373/4885MAPT 4707/4885MAPK1 3715/4885 |
| US-20110306658-A1 | Novel compound obtained from gamboge resin, and medical uses of the same | PGGT1B, RXRG, PTGIS | TP53 2012/4885MAPT 4736/4885MAPK1 3234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.