Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28283697 | 1.00 | ATM (0.40) | ATMMAPK1KMT2AALDH1A1MEN1 | |
| SCHEMBL21993489 | 0.94 | ATM (0.45) | ATMMAPK1KMT2AALDH1A1MEN1 | |
| SCHEMBL12966705 | 0.82 | ATM (0.43) | ATMMAPK1KMT2AALDH1A1MEN1 | |
| SCHEMBL12788429 | 0.82 | ATM (0.43) | ATMMAPK1KMT2AALDH1A1MEN1 | |
| SCHEMBL17618091 | 0.82 | ATM (0.43) | ATMMAPK1KMT2AALDH1A1MEN1 | |
| SCHEMBL20569702 | 0.80 | POLB (0.42) | KMT2AALDH1A1MEN1L3MBTL1 | |
| SCHEMBL14509655 | 0.80 | HTT (0.35) | — | |
| SCHEMBL24359063 | 0.79 | HDAC8 (0.41) | HRH3 | |
| SCHEMBL12621131 | 0.79 | HRH3 (0.35) | HRH3L3MBTL1 | |
| SCHEMBL25540249 | 0.79 | HDAC8 (0.41) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436011-B2 | Pyridinopyridinone derivatives, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2013-05-07 | — | — | US | disclosed |