Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8234772 | 0.92 | HTR2C (0.45) | HTR2CTDP1SLC18A3SIGMAR1KCNH2 | |
| SCHEMBL11519234 | 0.85 | MAOA (0.55) | HTR2CTDP1SLC18A3SIGMAR1KCNH2 | |
| SCHEMBL11832143 | 0.85 | MAOA (0.55) | HTR2CSLC18A3SIGMAR1KCNH2HRH3 | |
| SCHEMBL22117595 | 0.83 | SLC18A3 (0.48) | HTR2CTDP1SLC18A3SIGMAR1SLC6A4 | |
| SCHEMBL26041153 | 0.82 | SLC18A3 (0.47) | HTR2CTDP1SLC18A3SIGMAR1SLC6A4 | |
| Hydrochloric Acid SCHEMBL22117660 | 0.82 | HTR2C (0.47) | HTR2CTDP1SLC18A3SIGMAR1SLC6A4 | |
| SCHEMBL13979458 | 0.82 | HRH3 (0.49) | TDP1KCNH2HRH3USP30HTR2A | |
| SCHEMBL16829576 | 0.82 | HTR2C (0.68) | HTR2CSLC18A3SIGMAR1SLC6A4HTR2A | |
| SCHEMBL14990606 | 0.81 | MAOA (0.53) | HTR2CTDP1SLC18A3SIGMAR1SLC6A4 | |
| SCHEMBL4953608 | 0.81 | HRH3 (0.49) | SLC18A3SIGMAR1KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE44205-E1 | Adenosine A2a receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-05-07 | — | — | US | disclosed |