Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.62 |
| ▸ | KDR | P35968 | 7/20 | 0.62 |
| ▸ | RAF1 | P04049 | 6/20 | 0.62 |
| ▸ | BRAF | P15056 | 6/20 | 0.62 |
| ▸ | RET | P07949 | 4/20 | 0.62 |
| ▸ | MAP3K20 | Q9NYL2 | 4/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.62 |
| ▸ | KIT | P10721 | 3/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.62 |
| ▸ | FLT1 | P17948 | 3/20 | 0.62 |
| ▸ | EPHA1 | P21709 | 3/20 | 0.62 |
| ▸ | TTK | P33981 | 3/20 | 0.62 |
| ▸ | FLT4 | P35916 | 3/20 | 0.62 |
| ▸ | FLT3 | P36888 | 3/20 | 0.62 |
| ▸ | CLK1 | P49759 | 3/20 | 0.62 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.62 |
| ▸ | CDK17 | Q00537 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14911164 | 0.92 | ABL1 (0.73) | ABL1MAPK14KDRRAF1BRAF | |
| SCHEMBL19888749 | 0.86 | ABL1 (0.67) | ABL1MAPK14KDRRAF1BRAF | |
| SCHEMBL19888723 | 0.86 | ABL1 (0.59) | ABL1MAPK14KDRRAF1BRAF | |
| SCHEMBL10163140 | 0.86 | KDR (0.55) | ABL1MAPK14KDRRAF1BRAF | |
| SCHEMBL29834780 | 0.85 | ABL1 (0.64) | ABL1MAPK14KDRRAF1BRAF | |
| SCHEMBL17914280 | 0.85 | ABL1 (0.57) | ABL1MAPK14KDRRAF1BRAF | |
| SCHEMBL2560625 | 0.85 | BRAF (0.59) | ABL1MAPK14KDRRAF1BRAF | |
| SCHEMBL17471735 | 0.85 | RAF1 (0.59) | ABL1MAPK14KDRRAF1BRAF | |
| SCHEMBL19888732 | 0.85 | RIPK2 (0.70) | ABL1MAPK14KDRRAF1BRAF | |
| SCHEMBL19888717 | 0.85 | ABL1 (0.65) | ABL1MAPK14KDRRAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016203352-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | MOHAN M ALAPATI (IN) | 2016-12-22 | — | — | WO | disclosed |
| WO-2016203337-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | MOHAN M ALAPATI (IN) | 2016-12-22 | — | — | WO | disclosed |
| EP-2589384-A1 | New Pharmaceutical Compositions for the Treatment of Hyper-Proliferative Disorders | Bayer Healthcare LLC (US) | 2013-05-08 | — | — | EP | disclosed |