Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.73 |
| ▸ | RAF1 | P04049 | 10/20 | 0.72 |
| ▸ | KDR | P35968 | 8/20 | 0.72 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.72 |
| ▸ | BRAF | P15056 | 5/20 | 0.72 |
| ▸ | RET | P07949 | 4/20 | 0.72 |
| ▸ | MAP3K20 | Q9NYL2 | 4/20 | 0.72 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.72 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.72 |
| ▸ | KIT | P10721 | 3/20 | 0.72 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.72 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.72 |
| ▸ | FLT1 | P17948 | 3/20 | 0.72 |
| ▸ | EPHA1 | P21709 | 3/20 | 0.72 |
| ▸ | TTK | P33981 | 3/20 | 0.72 |
| ▸ | FLT4 | P35916 | 3/20 | 0.72 |
| ▸ | FLT3 | P36888 | 3/20 | 0.72 |
| ▸ | CLK1 | P49759 | 3/20 | 0.72 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.72 |
| ▸ | CDK17 | Q00537 | 3/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19888749 | 0.94 | ABL1 (0.67) | ABL1RAF1KDRMAPK14BRAF | |
| SCHEMBL19888733 | 0.92 | ABL1 (0.65) | ABL1RAF1KDRMAPK14BRAF | |
| SCHEMBL19878466 | 0.92 | RAF1 (0.72) | ABL1RAF1KDRMAPK14BRAF | |
| SCHEMBL19888732 | 0.92 | RIPK2 (0.70) | ABL1RAF1KDRMAPK14BRAF | |
| SCHEMBL19888717 | 0.92 | ABL1 (0.65) | ABL1RAF1KDRMAPK14BRAF | |
| SCHEMBL14923005 | 0.92 | ABL1 (0.63) | ABL1RAF1KDRMAPK14BRAF | |
| SCHEMBL10105554 | 0.92 | ABL1 (0.67) | ABL1RAF1KDRMAPK14BRAF | |
| SCHEMBL1660178 | 0.92 | RAF1 (0.68) | ABL1RAF1KDRMAPK14BRAF | |
| SCHEMBL1660412 | 0.91 | ABL1 (0.63) | ABL1RAF1KDRMAPK14BRAF | |
| SCHEMBL19888727 | 0.91 | RAF1 (0.75) | ABL1RAF1KDRMAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10822305-B2 | Process for the preparation of 4-(4-amino-3-fluorophenoxy)-N-methylpyyridine-2-carboxamide | BAYER HEALTHCARE LLC (US) | 2020-11-03 | — | — | US | disclosed |
| US-20190144391-A1 | Process for the Preparation of 4-(4-amino-3-fluorophenoxy)-N-methylpyyridine-2-carboxamide | BAYER HEALTHCARE LLC (US) | 2019-05-16 | — | — | US | disclosed |
| US-20170334857-A1 | Method of Purifying and using 4-chloro-n-methy1-2-pyridinecarboxamide | BAYER HEALTHCARE LLC (US) | 2017-11-23 | — | — | US | disclosed |
| US-20170247331-A1 | PROCESS FOR THE PREPARATION OF 4-[-(AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE AND ITS POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2017-08-31 | — | — | US | disclosed |
| US-20170247331-A1 | PROCESS FOR THE PREPARATION OF 4-[-(AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE AND ITS POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2017-08-31 | — | — | US | disclosed |
| US-20170247331-A1 | PROCESS FOR THE PREPARATION OF 4-[-(AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE AND ITS POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2017-08-31 | — | — | US | disclosed |
| US-20170057918-A1 | PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-ETHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-03-02 | — | — | US | disclosed |
| US-9458107-B2 | Process for the preparation of 4-{4-[({[4 chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorphenoxy-N-ethylpyridie-carboxamide, its salts and monohydrate | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-10-04 | — | — | US | disclosed |
| WO-2016051422-A2 | PROCESS FOR THE PREPARATION OF 4-[4-({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE AND ITS POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2016-04-07 | — | — | WO | disclosed |
| EP-2558448-B1 | PROCESS FOR THE PREPARATION OF 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)-PHENYL]AMINO}CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE | BAYER HEALTHCARE LLC (US) | 2015-05-20 | — | — | EP | disclosed |
| US-20140221661-A1 | PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-ETHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-08-07 | — | — | US | disclosed |
| US-8748622-B2 | Process for the preparation of 4-{4[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-06-10 | — | — | US | disclosed |
| US-20130116442-A1 | PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-09 | — | — | US | disclosed |
| US-7910059-B2 | For the determination of an analyte or analytes such as proteins, peptides, nucleic acids, carbohydrates, lipids, steroids and small molecules by mass analysis | DH TECHNOLOGIES PTE. LTD. (SG) | 2011-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144391-A1 | Process for the Preparation of 4-(4-amino-3-fluorophenoxy)-N-methylpyyridine-2-carboxamide | DNPEP, NPEPPS, TET3 | ABL1 24/4885RAF1 3657/4885KDR 2897/4885 |
| US-20170334857-A1 | Method of Purifying and using 4-chloro-n-methy1-2-pyridinecarboxamide | TET2, NPEPPS, METAP1 | ABL1 72/4885RAF1 4029/4885KDR 3758/4885 |
| US-20170247331-A1 | PROCESS FOR THE PREPARATION OF 4-[-(AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE AND ITS POLYMORPHS THEREOF | CYP3A4, CYP4F2, CYP4B1 | ABL1 403/4885RAF1 2861/4885KDR 3769/4885 |
| US-20140221661-A1 | PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-ETHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE | ACMSD, DNPEP, CPS1 | ABL1 32/4885RAF1 2344/4885KDR 2111/4885 |
| US-20170057918-A1 | PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-ETHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE | ACMSD, DNPEP, CPS1 | ABL1 32/4885RAF1 2345/4885KDR 2052/4885 |
| US-20130116442-A1 | PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE | ACMSD, DNPEP, CPS1 | ABL1 34/4885RAF1 2574/4885KDR 2454/4885 |
| US-10822305-B2 | Process for the preparation of 4-(4-amino-3-fluorophenoxy)-N-methylpyyridine-2-carboxamide | DNPEP, NPEPPS, TET3 | ABL1 22/4885RAF1 3629/4885KDR 2813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.