Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 3/20 | 0.35 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14923322 | 0.94 | KMT2A (0.40) | MEN1KMT2AALDH1A1SIGMAR1 | |
| SCHEMBL14923304 | 0.84 | KDM5A (0.44) | KMT2AKDM5APHF8KDM2AKDM4C | |
| SCHEMBL14923346 | 0.77 | HPGD (0.39) | MEN1KMT2AKDM5APHF8KDM2A | |
| SCHEMBL14923302 | 0.77 | HPGD (0.39) | MEN1KMT2AKDM5APHF8KDM2A | |
| SCHEMBL14923373 | 0.77 | KDM5A (0.35) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL14923374 | 0.77 | EPHX1 (0.42) | MEN1KMT2AKDM5APHF8KDM2A | |
| SCHEMBL14923312 | 0.77 | HPGD (0.35) | MEN1KMT2AKDM5APHF8KDM2A | |
| SCHEMBL17551587 | 0.76 | HPGD (0.34) | MEN1KMT2AKDM5APHF8KDM2A | |
| SCHEMBL14923233 | 0.74 | ACKR3 (0.47) | MEN1KMT2AALDH1A1 | |
| SCHEMBL17715619 | 0.73 | CTSD (0.38) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699455-B1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-05-08 | — | — | EP | disclosed |