⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14925709 | 1.00 | — | — | |
| SCHEMBL16943215 | 0.86 | — | — | |
| SCHEMBL25485086 | 0.86 | — | — | |
| SCHEMBL25485084 | 0.84 | — | — | |
| SCHEMBL21675978 | 0.84 | — | — | |
| SCHEMBL17250026 | 0.82 | — | — | |
| SCHEMBL17250027 | 0.80 | — | — | |
| SCHEMBL15247431 | 0.79 | — | — | |
| SCHEMBL15905930 | 0.78 | — | — | |
| SCHEMBL25485097 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160348109-A1 | POST-SYNTHETIC CHEMICAL MODIFICATION OF RNA AT THE 2'-POSITION OF THE RIBOSE RING VIA \"CLICK\" CHEMISTRY | SIRNA THERAPEUTICS INC (US) | 2016-12-01 | — | — | US | disclosed |
| US-20150322433-A1 | POST-SYNTHETIC ORTHOGANAL AMIDATION PLUS METAL CATALYZED AZIDE-ALKYNE CYCLOADDITION CLICK CHEMISTRY ON siRNA | SIRNA THERAPEUTICS, INC. (US) | 2015-11-12 | — | — | US | disclosed |
| US-20130116419-A1 | POST-SYNTHETIC CHEMICAL MODIFICATION OF RNA AT THE 2'-POSITION OF THE RIBOSE RING VIA \"CLICK\" CHEMISTRY | SIRNA THERAPEUTICS, INC. | 2013-05-09 | — | — | US | disclosed |