⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922639 | 1.00 | — | — | |
| SCHEMBL15164845 | 0.82 | CA12 (0.41) | — | |
| SCHEMBL7673327 | 0.80 | CA12 (0.46) | — | |
| SCHEMBL5387999 | 0.80 | CA2 (0.52) | — | |
| SCHEMBL18757941 | 0.76 | — | — | |
| SCHEMBL24502974 | 0.76 | CA12 (0.39) | — | |
| SCHEMBL20749977 | 0.76 | CA12 (0.39) | — | |
| SCHEMBL1492564 | 0.76 | PIK3CD (0.47) | — | |
| SCHEMBL23634053 | 0.74 | CA12 (0.42) | — | |
| SCHEMBL485398 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300472-B1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2012-01-18 | — | — | EP | claimed |
| JP-2011524867-A | — | — | 2011-09-08 | — | — | JP | claimed |
| EP-2300472-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2011-03-30 | — | — | EP | claimed |
| US-7683097-B2 | Topoisomerase inhibitors | Propharmacon Inc. (US) | 2010-03-23 | — | — | US | claimed |
| US-20090325988-A1 | Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-12-31 | — | — | US | claimed |
| WO-2009149139-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-10 | — | — | WO | claimed |
| US-12441707-B2 | Indazole compounds | TYRA BIOSCIENCES, INC. (US) | 2025-10-14 | — | — | US | disclosed |
| CN-117813302-A | Substituted tetrahydrofuran-2-carboxamides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| US-20230115528-A1 | INDAZOLE COMPOUNDS | TYRA BIOSCIENCES, INC. | 2023-04-13 | — | — | US | disclosed |
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2021138391-A1 | INDAZOLE COMPOUNDS | TYRA BIOSCIENCES, INC. (US) | 2021-07-08 | — | — | WO | disclosed |
| US-10806726-B2 | Methods of using indazole-3-carb oxamides and their use as Wnt/B-catenin signaling pathway inhibitors | SAMUMED, LLC (US) | 2020-10-20 | — | — | US | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |
| WO-2006022955-A2 | TOPOISOMERASE INHIBITORS | PROPHARMACON, INC. (US) | 2006-03-02 | — | — | WO | disclosed |
| EP-1278723-B1 | P-(SULFONYL)-ARYL AND -HETEROARYL AMINES | HOFFMANN LA ROCHE (CH) | 2005-08-31 | — | — | EP | disclosed |
| US-20050070562-A1 | Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. | 2005-03-31 | — | — | US | disclosed |
| EP-1278723-A2 | P-(SULFONYL)-ARYL AND -HETEROARYL AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-01-29 | — | — | EP | disclosed |
| US-20020052349-A1 | p-(sulfonyl) aryl and heteroarylamines as anti-inflammatory agents | SYNTEX (U.S.A.) LLC | 2002-05-02 | — | — | US | disclosed |
| WO-2001083434-A2 | P-(SULFONYL)-ARYL AND HETEROARYLS AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-08 | — | — | WO | disclosed |
| US-4001254-A | ISOTHIOCYANOPYRIDINE DERIVATIVES | CIBA-GEIGY CORPORATION (US) | 1977-01-04 | — | — | US | disclosed |