Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.56 |
| ▸ | WNT3A | P56704 | 3/20 | 0.53 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1493028 | 0.83 | PSEN1 (0.68) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492776 | 0.83 | WNT3A (0.52) | KMT2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1779524 | 0.82 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492763 | 0.82 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1780009 | 0.82 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492961 | 0.81 | WNT3A (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1782313 | 0.79 | NPC1 (0.69) | KMT2ANPC1MAPTPSEN1PSEN2 | |
| SCHEMBL1780926 | 0.77 | PSEN1 (0.61) | KMT2ANPC1MAPTPSEN1PSEN2 | |
| SCHEMBL31078859 | 0.77 | KMT2A (1.00) | KMT2ANPC1MAPTMAPK1RAB9A | |
| SCHEMBL1492659 | 0.77 | PSEN1 (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | claimed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | claimed |