Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPM2A | O95278 | 1/20 | 0.50 |
| ▸ | PTPRC | P08575 | 1/20 | 0.50 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.50 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.50 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 5/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2605170 | 0.84 | EPM2A (0.53) | EPM2APTPRCPTPN6CDC14APTPN22 | |
| Benzene SCHEMBL29028842 | 0.81 | EPM2A (0.50) | EPM2APTPRCPTPN6CDC14APTPN22 | |
| SCHEMBL827855 | 0.80 | EPM2A (0.62) | EPM2APTPRCPTPN6CDC14APTPN22 | |
| SCHEMBL12761344 | 0.79 | EPM2A (0.49) | EPM2APTPRCPTPN6CDC14APTPN22 | |
| SCHEMBL1602098 | 0.77 | EPM2A (0.50) | EPM2APTPRCPTPN6CDC14APTPN22 | |
| Aniline SCHEMBL29183835 | 0.76 | EPM2A (0.47) | EPM2APTPRCPTPN6CDC14APTPN22 | |
| SCHEMBL31292430 | 0.75 | EPM2A (0.53) | EPM2APTPRCPTPN6CDC14APTPN22 | |
| SCHEMBL31280683 | 0.75 | ESR1 (0.53) | EPM2APTPRCPTPN6CDC14APTPN22 | |
| SCHEMBL15582376 | 0.75 | EPM2A (0.56) | EPM2APTPRCPTPN6CDC14APTPN22 | |
| SCHEMBL18501701 | 0.74 | DYRK1A (0.59) | EPM2APTPRCPTPN6CDC14APTPN22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118234-A1 | Urea Compounds as Gamma Secretase Modulators | AMGEN INC. | 2011-05-19 | — | — | US | disclosed |
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118234-A1 | Urea Compounds as Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | EPM2A 974/4885PTPRC 4192/4885PTPN6 4788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.