EPM2A — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13734913	1.00	2/20
SCHEMBL13737097	1.00	2/20
SCHEMBL15829183	0.78	2/20
SCHEMBL15829184	0.78	2/20
SCHEMBL18231232	0.77	2/20
SCHEMBL15829185	0.77	2/20
SCHEMBL15829181	0.77	2/20
SCHEMBL15829186	0.75	2/20
SCHEMBL15829159	0.74	2/20
SCHEMBL15829187	0.72	2/20
SCHEMBL15829167	0.72	2/20
SCHEMBL13734961	0.70	2/20
SCHEMBL15829168	0.66	2/20
SCHEMBL15829160	0.65	2/20
SCHEMBL15829166	0.64	2/20
SCHEMBL15829174	0.61	2/20
SCHEMBL15829172	0.61	2/20
SCHEMBL15829188	0.58	2/20
SCHEMBL15829190	0.55	2/20
SCHEMBL13739517	0.54	2/20

Clinical trials — most relevant to EPM2A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Natural History and Functional Status Study of Patients With Lafora Disease	nan	COMPLETED
Intravenous VAL-1221 Lafora Expanded Access Protocol	nan	AVAILABLE
The Classification and Cause of Leukodystrophies of Unknown Cause	nan	COMPLETED
Natural History of the Leukodystrophies	nan	COMPLETED
LAMA2-related Muscular Dystrophy Brain Study	nan	WITHDRAWN
Natural History Study of Children With LAMA2-related Dystrophies	nan	RECRUITING
Characterization of the Natural History of LAMA2-RD and Identification of Novel Disease Biomarkers	nan	RECRUITING
Genetic Studies of Lysosomal Storage Disorders	nan	ENROLLING_BY_INVITATION
Human Epilepsy Genetics--Neuronal Migration Disorders Study	nan	RECRUITING
Genetics of Epilepsy and Related Disorders	nan	RECRUITING
MEHMO Natural History and Biomarkers	nan	RECRUITING
Autoimmune Cytopenia: Genetics and Pathophysiological Mechanism in Pediatric Evans Syndrome	nan	UNKNOWN
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
Prospective Phenotyping for Genetic Subtypes of Early-onset Atrial Fibrillation	nan	COMPLETED
The Nosology and Etiology of Leukodystrophies of Unknown Causes	nan	COMPLETED
Registry and Natural History Study for Progressive Myoclonus Epilepsy Type 1 (EPM1)	nan	RECRUITING
Rolandic Epilepsy Genomewide Association International Study	nan	COMPLETED
The Myelin Disorders Biorepository Project	nan	RECRUITING
Genetic Developmental and Epileptic Encephalopathy Natural History Study for Clinical Trial Readiness	nan	RECRUITING
Genetic Study of Familial Epilepsy	nan	COMPLETED
Genetics of Rolandic Epilepsy	nan	COMPLETED
Identification of New FTLD Genes	nan	UNKNOWN
Amyotrophic Lateral Sclerosis (ALS) Families Project	nan	RECRUITING
Parkinson's Foundation PD GENEration Genetic Registry	nan	RECRUITING
Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis)	nan	COMPLETED
Genotype, Phenotype, and Disease Progression of Developmental Epileptic Encephalopathy With Onset Before 2 Years of Age	nan	RECRUITING
Finding Genes With NGS Techniques in Whom Mutations Cause Neurological Diseases	nan	UNKNOWN
Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)	nan	RECRUITING
Evaluation of Phenotypic and Genetic Properties in Male Subjects Affected By Hypohidrotic Ectodermal Dysplasia (ECP-012)	nan	COMPLETED
PKP2-ACM Natural History Study	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a EPM2A binder may also engage these)

Protein	Name	Similarity
Q1M199	—	1.000	Q1M199 →
Q9WUA5	—	0.997	Q9WUA5 →
Q91XQ2	—	0.995	Q91XQ2 →
Q5R5F8	—	0.968	Q5R5F8 →
Q9NVE7	—	0.966	Q9NVE7 →
Q4R4U1	—	0.965	Q4R4U1 →
Q923S8	—	0.964	Q923S8 →
Q29513	—	0.960	Q29513 →
P13255	—	0.960	P13255 →
Q6NYU2	—	0.960	Q6NYU2 →
GNMT	Glycine N-methyltransferase	0.959	landscape →
P10868	—	0.959	P10868 →
O35969	—	0.958	O35969 →
P11716	—	0.957	P11716 →
Q80YV4	—	0.957	Q80YV4 →
D2XV59	—	0.957	D2XV59 →
Q6DFV5	—	0.957	Q6DFV5 →
Q96RR1	—	0.956	Q96RR1 →
Q9DAK3	—	0.956	Q9DAK3 →
E9PZQ0	—	0.956	E9PZQ0 →
Q9QXF8	—	0.955	Q9QXF8 →
Q9BYZ6	—	0.955	Q9BYZ6 →
Q29555	—	0.954	Q29555 →
HELZ	Probable helicase with zinc finger domain	0.954	landscape →
O94844	—	0.954	O94844 →
RYR1	Ryanodine receptor 1	0.954	landscape →
Q5ZIW1	—	0.953	Q5ZIW1 →
P11029	—	0.953	P11029 →
F1LMY4	—	0.953	F1LMY4 →
Q9Y2S7	—	0.953	Q9Y2S7 →