Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 8/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.49 |
| ▸ | WNT3A | P56704 | 2/20 | 0.44 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492914 | 0.91 | MAPK1 (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492707 | 0.89 | MAPK1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492940 | 0.88 | MAPK1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27809676 | 0.88 | MAPK1 (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7955634 | 0.87 | MAPK1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492730 | 0.86 | MAPK1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492735 | 0.85 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492906 | 0.84 | PSEN1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492934 | 0.84 | PSEN1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492888 | 0.84 | PORCN (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | claimed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | claimed |
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |