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Sugi Predict / Targets / PORCN

PORCN

Protein-serine O-palmitoleoyltransferase porcupine · Q9H237 · PORCN on Sugi Atlas →

7,391 patent compounds predicted against PORCN, 4,153 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL248713 SCHEMBL248713 0.50 10/20
SCHEMBL1723533 SCHEMBL1723533 0.75 8/20
SCHEMBL2572179 SCHEMBL2572179 0.48 7/20
SCHEMBL1723597 SCHEMBL1723597 0.81 5/20
SCHEMBL1724911 SCHEMBL1724911 0.68 5/20
SCHEMBL1722771 SCHEMBL1722771 0.76 4/20
SCHEMBL246101 SCHEMBL246101 0.65 4/20
SCHEMBL1726132 SCHEMBL1726132 0.64 4/20
SCHEMBL558511 SCHEMBL558511 0.60 4/20
SCHEMBL248089 SCHEMBL248089 0.58 4/20
SCHEMBL1059288 SCHEMBL1059288 0.46 4/20
SCHEMBL1064147 SCHEMBL1064147 0.35 4/20
Wnt-974 Wnt-974 (SCHEMBL1723611) 1.00 3/20
SCHEMBL1492829 SCHEMBL1492829 0.73 3/20
SCHEMBL1492885 SCHEMBL1492885 0.71 3/20
SCHEMBL1492983 SCHEMBL1492983 0.69 3/20
SCHEMBL1493028 SCHEMBL1493028 0.68 3/20
SCHEMBL1725838 SCHEMBL1725838 0.65 3/20
SCHEMBL1492902 SCHEMBL1492902 0.62 3/20
SCHEMBL1492879 SCHEMBL1492879 0.61 3/20

Clinical trials — most relevant to PORCN by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R PHASE4WITHDRAWN
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis PHASE2UNKNOWN
Hereditary Sensory Neuropathy Serine Trial PHASE2UNKNOWN
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients PHASE2COMPLETED
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease PHASE2COMPLETED
NEO100 and High-Grade Meningioma PHASE2RECRUITING
The Effects of Coenzyme A Combined With Abiraterone on Patients With CRPC PHASE1/PHASE2UNKNOWN
Lovaza's Effect on the Activation of Platelets PHASE2COMPLETED
Activity of Regorafenib in Combination With Chemotherapy in Patients With Advanced Biliary Tract Cancer PHASE1/PHASE2COMPLETED
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC PHASE2COMPLETED
Simvastatin Therapy in Smith-Lemli-Opitz Syndrome PHASE2COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
Polycystic Ovary Syndrome in Type 1 Diabetes nanNOT_YET_RECRUITING
Evaluating a Novel Individualised Treatment Strategy for Carbapenem-Resistant Gram-Negative Bacteria Infections nanUNKNOWN
Effects of Parenteral L-carnitine Supplementation in Premature Neonates nanCOMPLETED
Targeting zDHHC Enzymes to Counteract Alzheimer's Disease nanNOT_YET_RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Systemic Biomarkers of Brain Injury From Hyperammonemia nanRECRUITING
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Impact Of Choline in Patients With NAFLD nanUNKNOWN
Epidemiology of Atherosclerosis nanCOMPLETED
Familial Partial Lipodystrophy Study nanCOMPLETED
Fatty Acid Oxidation Defects and Insulin Sensitivity nanCOMPLETED
Energy Balance and Weight Gain With Ivacaftor Treatment nanCOMPLETED
Impaired Secretory IgA and Mucosal Immunity in Cystic Fibrosis nanUNKNOWN
Evaluation of Blood Protein O-GlcNAcylation Levels in Children nanRECRUITING
Immune Cell Response to Stimuli nanRECRUITING
11C-Acetate PET/CT Non-FDG-Avid Tumors nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a PORCN binder may also engage these)

ProteinNameSimilarity
Q9JJJ7 — 1.000 Q9JJJ7 →
Q8BMT9 — 0.975 Q8BMT9 →
Q8CHK3 — 0.970 Q8CHK3 →
MBOAT4 Membrane-bound ghrelin O-acyltransferase MBOAT4 0.960 landscape →
B1Q005 — 0.958 B1Q005 →
P0C7A3 — 0.953 P0C7A3 →
G6PC1 Glucose-6-phosphatase catalytic subunit 1 0.952 landscape →
Q9CAN8 — 0.952 Q9CAN8 →
HHAT Protein-cysteine N-palmitoyltransferase HHAT 0.951 landscape →
Q9HCP6 — 0.950 Q9HCP6 →
MBOAT7 Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 0.950 landscape →
Q19KA1 — 0.947 Q19KA1 →
Q0VCY6 — 0.946 Q0VCY6 →
Q29RU6 — 0.946 Q29RU6 →
Q8BMD6 — 0.945 Q8BMD6 →
Q9NX78 — 0.945 Q9NX78 →
Q7TNV1 — 0.944 Q7TNV1 →
Q924Z5 — 0.943 Q924Z5 →
Q9JJQ0 — 0.943 Q9JJQ0 →
P51811 — 0.942 P51811 →
P43428 — 0.942 P43428 →
Q9QXY7 — 0.942 Q9QXY7 →
O57426 — 0.941 O57426 →
Q71RH2 — 0.941 Q71RH2 →
O19133 — 0.941 O19133 →
Q15035 — 0.941 Q15035 →
Q9Y5Y5 — 0.941 Q9Y5Y5 →
P35576 — 0.941 P35576 →
GPAA1 GPI-anchor transamidase component GPAA1 0.940 landscape →
Q49LS5 — 0.940 Q49LS5 →