Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | PSEN1 | P49768 | 9/20 | 0.58 |
| ▸ | PSEN2 | P49810 | 9/20 | 0.58 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.58 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.58 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.58 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492870 | 0.85 | PSEN1 (0.67) | KMT2ASMN1; SMN2CYP3A4PSEN1PSEN2 | |
| SCHEMBL1493028 | 0.85 | PSEN1 (0.68) | MAPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492860 | 0.84 | CNR1 (0.68) | KMT2ASMN1; SMN2CYP3A4PSEN1PSEN2 | |
| SCHEMBL1492777 | 0.83 | NPC1 (0.63) | MAPTMEN1KMT2ATP53MAPK1 | |
| SCHEMBL1492821 | 0.83 | PSEN1 (0.63) | MAPTMEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL1493023 | 0.82 | CNR1 (0.65) | KMT2ASMN1; SMN2TP53POLBPSEN1 | |
| SCHEMBL1492969 | 0.81 | PSEN1 (0.67) | CYP2D6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492843 | 0.81 | NPC1 (0.64) | MAPTMEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL1781477 | 0.81 | PSEN1 (0.61) | CYP2D6PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492802 | 0.81 | MEN1 (0.59) | MAPTMEN1KMT2ASMN1; SMN2PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118234-A1 | Urea Compounds as Gamma Secretase Modulators | AMGEN INC. | 2011-05-19 | — | — | US | claimed |
| EP-2300427-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2011-03-30 | — | — | EP | claimed |
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | claimed |
| US-20110118234-A1 | Urea Compounds as Gamma Secretase Modulators | AMGEN INC. | 2011-05-19 | — | — | US | disclosed |
| US-20110118234-A1 | Urea Compounds as Gamma Secretase Modulators | AMGEN INC. | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118234-A1 | Urea Compounds as Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | MAPT 26/4885MEN1 3122/4885KMT2A 3895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.