Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | GCK | P35557 | 9/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1426929 | 0.85 | GCK (0.64) | RAB9ANPC1SMN1; SMN2HPGDGCK | |
| SCHEMBL2664728 | 0.84 | GCK (0.60) | RAB9ANPC1SMN1; SMN2HPGDGCK | |
| SCHEMBL13891667 | 0.84 | GCK (0.74) | RAB9ANPC1SMN1; SMN2HPGDGCK | |
| SCHEMBL1146562 | 0.84 | GCK (0.74) | RAB9ANPC1SMN1; SMN2HPGDGCK | |
| SCHEMBL1426992 | 0.83 | GCK (0.67) | RAB9ANPC1SMN1; SMN2HPGDGCK | |
| SCHEMBL1493685 | 0.83 | GCK (0.67) | RAB9ANPC1SMN1; SMN2HPGDGCK | |
| SCHEMBL1146565 | 0.80 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2HPGDGCK | |
| SCHEMBL2664748 | 0.80 | GCK (0.64) | RAB9ANPC1SMN1; SMN2HPGDGCK | |
| SCHEMBL2176809 | 0.80 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2HPGDGCK | |
| SCHEMBL1426952 | 0.79 | GCK (0.58) | RAB9ANPC1SMN1; SMN2HPGDGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301929-A1 | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes | AstraZeneca AB (Publ) (SE) | 2011-03-30 | — | — | EP | disclosed |