Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.75 |
| ▸ | FER | P16591 | 1/20 | 0.73 |
| ▸ | JAK2 | O60674 | 2/20 | 0.73 |
| ▸ | FLT3 | P36888 | 2/20 | 0.73 |
| ▸ | LCK | P06239 | 1/20 | 0.73 |
| ▸ | YES1 | P07947 | 1/20 | 0.73 |
| ▸ | LYN | P07948 | 1/20 | 0.73 |
| ▸ | FGR | P09769 | 1/20 | 0.73 |
| ▸ | SRC | P12931 | 1/20 | 0.73 |
| ▸ | PRKCA | P17252 | 1/20 | 0.73 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.73 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.73 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.73 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | HCK | P08631 | 1/20 | 0.57 |
| ▸ | ROS1 | P08922 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14931173 | 1.00 | SYK (0.75) | SYKKCNH2FERJAK2FLT3 | |
| SCHEMBL5026431 | 0.93 | SYK (0.80) | SYKKCNH2FERJAK2FLT3 | |
| SCHEMBL14908938 | 0.90 | SYK (0.75) | SYKKCNH2FERJAK2FLT3 | |
| SCHEMBL9110112 | 0.90 | SYK (0.75) | SYKKCNH2FERJAK2FLT3 | |
| SCHEMBL14929575 | 0.90 | SYK (0.75) | SYKKCNH2FERJAK2FLT3 | |
| SCHEMBL5027032 | 0.87 | FER (0.74) | SYKKCNH2FERJAK2FLT3 | |
| SCHEMBL9106552 | 0.86 | SYK (1.00) | SYKKCNH2FERJAK2FLT3 | |
| SCHEMBL14929934 | 0.84 | FER (1.00) | SYKKCNH2FERJAK2FLT3 | |
| SCHEMBL14910186 | 0.84 | FER (1.00) | SYKKCNH2FERJAK2FLT3 | |
| SCHEMBL14910185 | 0.84 | FER (1.00) | SYKKCNH2FERJAK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895585-B2 | Nicotinamide derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8809371-B2 | — | — | 2014-08-19 | — | — | US | disclosed |
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | SYK, CD38, BTK | SYK 1/4885KCNH2 1263/4885FER 919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.