Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 11/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2547939 | 0.86 | CSNK2A1 (0.54) | KDM4EALDH1A1GAAHSD17B10MEN1 | |
| SCHEMBL2553024 | 0.80 | ERN1 (0.58) | KDM4EALDH1A1GAAHSD17B10MEN1 | |
| SCHEMBL2573383 | 0.80 | MEN1 (0.43) | KDM4EALDH1A1GAAHSD17B10MEN1 | |
| SCHEMBL12858762 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1GAAHSD17B10MEN1 | |
| SCHEMBL10965294 | 0.79 | ALDH1A1 (0.73) | KDM4EALDH1A1GAAHSD17B10MEN1 | |
| SCHEMBL22840696 | 0.78 | KDM4E (0.46) | KDM4EALDH1A1GAAHSD17B10MEN1 | |
| SCHEMBL2556031 | 0.77 | ERN1 (0.61) | KDM4EALDH1A1GAAHSD17B10MEN1 | |
| SCHEMBL2570250 | 0.76 | HPGD (0.43) | KDM4EALDH1A1GAAHSD17B10MEN1 | |
| SCHEMBL30406437 | 0.76 | CYP2D6 (0.51) | KDM4EALDH1A1GAAHSD17B10MEN1 | |
| SCHEMBL2555270 | 0.76 | CYP2D6 (0.51) | KDM4EALDH1A1GAAHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130116247-A1 | IRE-1alpha INHIBITORS | MANNKIND CORPORATION (US) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116247-A1 | IRE-1alpha INHIBITORS | ERN1, XBP1, ERN2 | KDM4E 2975/4885ALDH1A1 2036/4885GAA 638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.