⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18133745 | 1.00 | — | — | |
| SCHEMBL14985384 | 1.00 | — | — | |
| SCHEMBL15038030 | 0.86 | — | — | |
| SCHEMBL21567214 | 0.85 | — | — | |
| SCHEMBL15038033 | 0.85 | — | — | |
| SCHEMBL18270978 | 0.85 | — | — | |
| SCHEMBL15038032 | 0.83 | CHRM5 (0.38) | — | |
| SCHEMBL10273035 | 0.80 | — | — | |
| SCHEMBL15038034 | 0.78 | NCF1 (0.48) | — | |
| SCHEMBL12371223 | 0.78 | NCF1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3368519-B1 | NOVEL HETEROCYCLIC ANTIESTROGENS | SUN PHARMA ADVANCED RES CO LTD (IN) | 2022-04-06 | — | — | EP | disclosed |
| US-20210053947-A1 | NOVEL HETEROCYCLIC ANTIESTROGENS | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2021-02-25 | — | — | US | disclosed |
| US-10865199-B2 | Heterocyclic antiestrogens | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2020-12-15 | — | — | US | disclosed |
| WO-2017072792-A1 | NOVEL HETEROCYCLIC ANTIESTROGENS | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2017-05-04 | — | — | WO | disclosed |
| WO-2016189011-A1 | HETEROCYCLIC ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2016-12-01 | — | — | WO | disclosed |
| US-20160347742-A1 | HETEROCYCLIC ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-12-01 | — | — | US | disclosed |
| US-9193714-B2 | Fluorinated estrogen receptor modulators and uses thereof | SERAGON PHARMACEUTICALS, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9187460-B2 | Estrogen receptor modulators and uses thereof | SERAGON PHARMACEUTICALS, INC. (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150258080-A1 | THERAPEUTIC COMBINATIONS WITH ESTROGEN RECEPTOR MODULATORS | GENENTECH, INC. (US) | 2015-09-17 | — | — | US | disclosed |
| US-20150258099-A1 | METHODS AND COMPOSITIONS FOR MODULATING ESTROGEN RECEPTOR MUTANTS | GENENTECH, INC. (US) | 2015-09-17 | — | — | US | disclosed |
| US-9078871-B2 | Estrogen receptor modulators and uses thereof | SERAGON PHARMACEUTICALS, INC. (US) | 2015-07-14 | — | — | US | disclosed |
| US-20150005286-A1 | FLUORINATED ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | SERAGON PHARMACEUTICALS, INC. | 2015-01-01 | — | — | US | disclosed |
| US-20140364427-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | SERAGON PHARMACEUTICALS, INC. | 2014-12-11 | — | — | US | disclosed |
| US-8853423-B2 | Indane estrogen receptor modulators and uses thereof | SERAGON PHARMACEUTICALS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-8703810-B2 | Estrogen receptor modulators and uses thereof | SERAGON PHARMACEUTICALS, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| US-20140107095-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | SERAGON PHARMACEUTICALS, INC. (US) | 2014-04-17 | — | — | US | disclosed |
| WO-2013090829-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2013-06-20 | — | — | WO | disclosed |
| WO-2013090836-A1 | FLUORINATED ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2013-06-20 | — | — | WO | disclosed |
| US-20130137746-A1 | INDANE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | US | disclosed |
| US-20130116232-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2013-05-09 | — | — | US | disclosed |