Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14306958 | 0.78 | HPGD (0.45) | SMN1; SMN2HPGDMAPTALDH1A1NPC1 | |
| SCHEMBL2041229 | 0.78 | HPGD (0.39) | SMN1; SMN2HPGDMAPTALDH1A1NPC1 | |
| SCHEMBL15073114 | 0.77 | HPGD (0.47) | SMN1; SMN2HPGDMAPTALDH1A1NPC1 | |
| SCHEMBL1121587 | 0.73 | HPGD (0.41) | SMN1; SMN2HPGDMAPTALDH1A1NPC1 | |
| SCHEMBL10367333 | 0.70 | SMN1; SMN2 (0.59) | SMN1; SMN2HPGDMAPTALDH1A1NPC1 | |
| SCHEMBL14281051 | 0.70 | HPGD (0.37) | SMN1; SMN2HPGDMAPTALDH1A1NPC1 | |
| SCHEMBL15572842 | 0.69 | HPGD (0.38) | SMN1; SMN2HPGDMAPTALDH1A1NPC1 | |
| SCHEMBL14281011 | 0.69 | HPGD (0.38) | SMN1; SMN2HPGDMAPTALDH1A1NPC1 | |
| SCHEMBL14306966 | 0.66 | HPGD (0.38) | SMN1; SMN2HPGDMAPTALDH1A1NPC1 | |
| SCHEMBL1121822 | 0.65 | HPGD (0.60) | SMN1; SMN2HPGDMAPTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130116235-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS | GENENTECH, INC. (US) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116235-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS | BTK, PDXK, TYK2 | SMN1; SMN2 3164/4885HPGD 1266/4885MAPT 3237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.