PDXK

Pyridoxal kinase · O00764 · PDXK on Sugi Atlas →

5,256 patent compounds predicted against PDXK, 4,330 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL126039	0.61	3/20
Hydrochloric Acid (SCHEMBL191715)	0.61	3/20
Pyridoxine (SCHEMBL3506)	0.60	3/20
Pyridoxine (SCHEMBL2322958)	0.60	3/20
SCHEMBL1049253	0.59	3/20
Pyridoxine (SCHEMBL42293)	0.58	3/20
Pyridoxine (SCHEMBL444525)	0.58	3/20
Pyridoxine (SCHEMBL2472293)	0.58	3/20
Pyridoxine (SCHEMBL1092163)	0.56	3/20
SCHEMBL1645737	0.56	3/20
Pyridoxine (SCHEMBL1685102)	0.56	3/20
Pyridoxine (SCHEMBL2162231)	0.56	3/20
SCHEMBL445657	0.56	3/20
SCHEMBL445658	0.56	3/20
SCHEMBL2563098	0.54	3/20
Pyridoxamine (SCHEMBL30408)	0.53	3/20
SCHEMBL1545975	0.53	3/20
Pyridoxamine (SCHEMBL48103)	0.51	3/20
Pyridoxamine (SCHEMBL561421)	0.51	3/20
Ginkgotoxin (SCHEMBL1848430)	0.49	3/20

Clinical trials — most relevant to PDXK by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Compare the Impact of Xuezhikang and Atorvastatin on Glucose Metabolism in Dyslipidemia Patients With Prediabetes	PHASE4	COMPLETED
Effect of a Basal/Pre-Meal Insulin Strategy (Detemir/Aspart) on Insulin Secretion and Action in Type 2 Diabetes	PHASE4	COMPLETED
The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway	PHASE4	COMPLETED
Acelarin First Line Randomised Pancreatic Study	PHASE2/PHASE3	SUSPENDED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Safety and Efficacy Study of Tarragon on Insulin Action in Humans	PHASE1/PHASE2	COMPLETED
Ketohexokinase Inhibition in NAFLD	PHASE2	COMPLETED
Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients	PHASE2	COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Contribution of Hyperinsulinemia vs. Hyperglycemia to Insulin Resistance in Type 1 Diabetes and Maturity Onset Diabetes of the Young, Type 2 (MODY2)	PHASE1	COMPLETED
Acute Effect of HP-211 (Axulin) on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans	PHASE1	COMPLETED
Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults	EARLY_PHASE1	COMPLETED
The Role of Sugars in Fat Accumulation in the Liver	nan	RECRUITING
GSD VI and GSD IX Natural History	nan	RECRUITING
Pyridoxine Effect on the Blood Glucose Level in Type 2 Diabetic Patients	nan	COMPLETED
Fluorodeoxyglucose Positron Emission Tomography (FDG PET) Findings in Patients With Phenylketonuria Before and After KUVAN Therapy	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Dried Fruit and Postprandial Glycemia Trial	nan	UNKNOWN
Randomized Controlled Clinical Trial to Investigate Effects of Vitamin K2 in COVID-19	nan	COMPLETED
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging	nan	COMPLETED
ProGRP, CgA, NSE and TUM2-PK in in Patients With Neuroendocrine Tumors	nan	UNKNOWN
Exercise in Type 1 Diabetes Mellitus	nan	COMPLETED
A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders	nan	RECRUITING
Genetic and Metabolic Disease in Children	nan	RECRUITING
Effects of Dual-Source Carbohydrate Intake and Liver Glycogen Repletion After Overnight Fasting.	nan	NOT_YET_RECRUITING
Relation Between Plasma Vitamin K2 and Glycemic Control and Metabolic Parameters in Type 2 Diabetic Patients.	nan	COMPLETED
Effect of Acute Fructose Load in Human	nan	COMPLETED
Studying Phosphorus Metabolism	nan	COMPLETED
Metabolomic Analysis of Body Fluid of Medulloblastoma in Children	nan	UNKNOWN
Primary Hyperoxaluria Mutation Genotyping/Phenotyping	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PDXK binder may also engage these)

Protein	Name	Similarity
Q8K183	—	1.000	Q8K183 →
O35331	—	1.000	O35331 →
P82197	—	0.998	P82197 →
O46560	—	0.998	O46560 →
Q0II59	—	0.997	Q0II59 →
P97328	—	0.955	P97328 →
Q4R4U1	—	0.955	Q4R4U1 →
Q5R5F8	—	0.955	Q5R5F8 →
Q9NVE7	—	0.954	Q9NVE7 →
NT5C3B	7-methylguanosine phosphate-specific 5'-nucleotidase	0.954	landscape →
KHK	Ketohexokinase	0.954	landscape →
P56965	—	0.953	P56965 →
Q9CWS0	—	0.952	Q9CWS0 →
Q02974	—	0.951	Q02974 →
DDAH1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0.951	landscape →
O08557	—	0.950	O08557 →
Q923S8	—	0.950	Q923S8 →
Q9QZ08	—	0.950	Q9QZ08 →
Q8BZF8	—	0.950	Q8BZF8 →
Q15124	—	0.949	Q15124 →
Q5RD71	—	0.949	Q5RD71 →
Q5ZM83	—	0.948	Q5ZM83 →
Q6GV29	—	0.947	Q6GV29 →
Q3UFY7	—	0.947	Q3UFY7 →
D3ZVR9	—	0.947	D3ZVR9 →
Q5U4X8	—	0.946	Q5U4X8 →
Q9H0P0	—	0.946	Q9H0P0 →
Q8R4N0	—	0.946	Q8R4N0 →
Q6AY30	—	0.946	Q6AY30 →
B1H369	—	0.946	B1H369 →