Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.81 |
| ▸ | GAA | P10253 | 2/20 | 0.81 |
| ▸ | CA12 | O43570 | 1/20 | 0.73 |
| ▸ | CA1 | P00915 | 1/20 | 0.73 |
| ▸ | CA2 | P00918 | 1/20 | 0.73 |
| ▸ | CA4 | P22748 | 1/20 | 0.73 |
| ▸ | CA6 | P23280 | 1/20 | 0.73 |
| ▸ | CA7 | P43166 | 1/20 | 0.73 |
| ▸ | TPMT | P51580 | 1/20 | 0.73 |
| ▸ | CA9 | Q16790 | 1/20 | 0.73 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.73 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.70 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9364577 | 0.98 | CYP1A2 (0.96) | CYP1A2TSHRCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL4818731 | 0.90 | ALDH1A1 (1.00) | CYP1A2TSHRCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL6872165 | 0.90 | TSHR (0.81) | CYP1A2TSHRCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL5074372 | 0.90 | CYP1A2 (0.81) | CYP1A2TSHRCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL2601961 | 0.90 | CYP1A2 (0.81) | CYP1A2TSHRCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL31369135 | 0.90 | CYP1A2 (0.81) | CYP1A2TSHRCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL7369813 | 0.90 | SLC22A6 (0.89) | CYP1A2TSHRCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL1333620 | 0.90 | CYP1A2 (0.81) | CYP1A2TSHRCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL4824662 | 0.90 | CYP1A2 (0.81) | CYP1A2TSHRCYP2C19CYP3A4CYP2C9 | |
| SCHEMBL12402407 | 0.89 | CYP1A2 (0.79) | CYP1A2TSHRCYP2C19CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 284 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102020546-B | PTP1B inhibitor and preparation and application in preparing drug for treating type 2 diabetes mellitus thereof | INST OCEANOLOGY CHINESE ACAD | 2013-07-24 | — | — | CN | claimed |
| CN-102100685-B | PTP1B inhibitor and synthetic method and application thereof | INST OCEANOLOGY CHINESE ACAD | 2012-12-26 | — | — | CN | claimed |
| CN-102020547-B | PTP1B (Protein Tyrosine Phosphatase 1B) inhibitor as well as chemical synthesis method and application thereof | INST OCEANOLOGY CHINESE ACAD | 2012-09-19 | — | — | CN | claimed |
| CN-102020545-B | PTP1B inhibitor, synthesis and application thereof | INST OCEANOLOGY CHINESE ACAD | 2012-09-12 | — | — | CN | claimed |
| CN-102020539-B | PTP1B (Protein Tyrosine Phosphatase 1B) inhibitor, synthesis and application thereof in preparation of drugs for treating type 2 diabetes mellitus | INST OCEANOLOGY CHINESE ACAD | 2012-09-12 | — | — | CN | claimed |
| CN-102020541-B | Protein tyrosine phosphatase 1B (PTP1B) inhibitor as well as chemical synthesis method and application thereof | INST OCEANOLOGY CHINESE ACAD | 2012-09-12 | — | — | CN | claimed |
| CN-102020538-B | PTP1B (Protein Tyrosine Phosphatase 1B) inhibitor as well as synthesis method and application thereof to preparation of type 2 diabetes medicament | INST OCEANOLOGY CHINESE ACAD | 2012-07-25 | — | — | CN | claimed |
| CN-101597213-B | Chemical synthesis method of bromphenol PTP1B inhibitor | INST OCEANOLOGY CHINESE ACAD | 2012-07-04 | — | — | CN | claimed |
| CN-102100685-A | PTP1B inhibitor and synthetic method and application thereof | INST OCEANOLOGY CHINESE ACAD | 2011-06-22 | — | — | CN | claimed |
| CN-102101825-A | PTP1B (Protein Tyrosine Phosphatase 1B) inhibitor, and synthesis and application thereof | INST OCEANOLOGY CHINESE ACAD | 2011-06-22 | — | — | CN | claimed |
| CN-102020547-A | PTP1B (Protein Tyrosine Phosphatase 1B) inhibitor as well as chemical synthesis method and application thereof | INST OF OCEANOLOGY OF CHINESE ACADEMY OF SCIENCES | 2011-04-20 | — | — | CN | claimed |
| CN-102020538-A | PTP1B (Protein Tyrosine Phosphatase 1B) inhibitor as well as synthesis method and application thereof to preparation of type 2 diabetes medicament | INST OF OCEANOLOGY OF CHINESE ACADEMY OF SCIENCES | 2011-04-20 | — | — | CN | claimed |
| CN-102020537-A | Protein tyrosine phosphatase 1B (PTP1B) inhibitor, and synthesis and application thereof | INST OF OCEANOLOGY OF CHINESE ACADEMY OF SCIENCES | 2011-04-20 | — | — | CN | claimed |
| CN-102020541-A | Protein tyrosine phosphatase 1B (PTP1B) inhibitor as well as chemical synthesis method and application thereof | INST OF OCEANOLOGY OF CHINESE ACADEMY OF SCIENCES | 2011-04-20 | — | — | CN | claimed |
| CN-102020546-A | PTP1B inhibitor and preparation and application in preparing drug for treating type 2 diabetes mellitus thereof | INST OF OCEANOLOGY OF CHINESE ACADEMY OF SCIENCES | 2011-04-20 | — | — | CN | claimed |
| CN-101597213-A | A kind of chemical synthesis process of bromphenol PTP 1 B inhibitor | INST OCEANOLOGY CHINESE ACAD (CN) | 2009-12-09 | — | — | CN | claimed |
| CN-101597217-A | PTP1B inhibitor and application synthetic and in preparation diabetes B medicine | INST OCEANOLOGY CHINESE ACAD (CN) | 2009-12-09 | — | — | CN | claimed |
| CN-101597216-A | Bromo PTP1B inhibitor reaches synthetic and uses in the preparation diabetes medicament | INST OCEANOLOGY CHINESE ACAD (CN) | 2009-12-09 | — | — | CN | claimed |
| US-6011178-A | Process for the preparation of 2-amino-4,5,3',4'-tetramethoxybenzophenone | LONZA, LTD. (CH) | 2000-01-04 | — | — | US | claimed |
| EP-0941987-A1 | Process for the preparation of 2-Amino-4,5,3',4'-tetramethoxybenzophenone | LONZA A.G. (CH) | 1999-09-15 | — | — | EP | claimed |