Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 7/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.56 |
| ▸ | CKS1B | P61024 | 1/20 | 0.55 |
| ▸ | SKP1 | P63208 | 1/20 | 0.55 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14932799 | 0.89 | HDAC4 (0.54) | HDAC4HDAC6HDAC8CKS1BSKP1 | |
| SCHEMBL14918562 | 0.88 | HDAC4 (0.59) | HDAC4HDAC6HDAC8HDAC1HDAC5 | |
| SCHEMBL14932796 | 0.87 | HDAC4 (0.60) | HDAC4HDAC6HDAC8CKS1BSKP1 | |
| SCHEMBL14932822 | 0.80 | HDAC4 (0.70) | HDAC4HDAC6HDAC8CKS1BSKP1 | |
| SCHEMBL14917981 | 0.79 | HDAC6 (0.57) | HDAC6HDAC8HDAC1HDAC5 | |
| SCHEMBL31675214 | 0.78 | HDAC6 (0.61) | HDAC4HDAC6HDAC8HDAC1HDAC5 | |
| SCHEMBL29878598 | 0.78 | HDAC6 (0.61) | HDAC4HDAC6HDAC8HDAC1HDAC5 | |
| SCHEMBL31045458 | 0.78 | CKS1B (0.48) | CKS1BSKP1SKP2FGFR3KDR | |
| SCHEMBL14918519 | 0.77 | HDAC6 (0.58) | HDAC4HDAC6HDAC8HDAC1HDAC5 | |
| SCHEMBL14932813 | 0.77 | HDAC4 (0.63) | HDAC4HDAC6HDAC8HDAC1HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066831-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |