Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 14/20 | 0.43 |
| ▸ | METAP2 | P50579 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | PIR | O00625 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.35 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | STK16 | O75716 | 1/20 | 0.35 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1490948 | 0.85 | BRAF (0.55) | FABP4BRAFMETAP2CYP2C9BMPR1B | |
| SCHEMBL1437566 | 0.79 | FABP4 (0.51) | FABP4BRAFMETAP2CYP3A4CYP2C9 | |
| SCHEMBL3529771 | 0.79 | FABP4 (0.53) | FABP4BRAFMETAP2MAP2K4 | |
| SCHEMBL413368 | 0.76 | CYP3A4 (0.62) | BRAFCYP3A4CYP2C9CYP2C19BMPR1B | |
| SCHEMBL25455943 | 0.75 | BRAF (0.55) | BRAFCYP3A4CYP2C9CYP2C19BMPR1B | |
| SCHEMBL912842 | 0.74 | BRAF (0.56) | FABP4BRAFCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29796692 | 0.74 | BRAF (0.56) | FABP4BRAFCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1592969 | 0.74 | FABP4 (0.46) | FABP4BRAFMETAP2CYP3A4CYP2C9 | |
| SCHEMBL1437490 | 0.74 | FABP4 (0.46) | FABP4BRAFMETAP2CYP3A4CYP2C9 | |
| SCHEMBL20399239 | 0.73 | BRAF (0.53) | BRAFCYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470539-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011025951-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | WO | disclosed |