Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9354553 | 0.98 | ALDH1A1 (0.52) | ALDH1A1TSHRCYP2C9MAPTKDM4E | |
| SCHEMBL2115865 | 0.87 | ALDH1A1 (0.61) | ALDH1A1TSHRCYP2C9MAPTKDM4E | |
| SCHEMBL1754710 | 0.87 | ALDH1A1 (0.61) | ALDH1A1TSHRCYP2C9MAPTKDM4E | |
| SCHEMBL1493366 | 0.82 | ALDH1A1 (0.48) | ALDH1A1TSHRCYP2C9MAPTKDM4E | |
| SCHEMBL11982570 | 0.81 | ALDH1A1 (0.47) | ALDH1A1TSHRCYP2C9MAPTKDM4E | |
| SCHEMBL12389858 | 0.81 | ALDH1A1 (0.47) | ALDH1A1TSHRCYP2C9MAPTKDM4E | |
| SCHEMBL3021948 | 0.81 | ALDH1A1 (0.55) | ALDH1A1TSHRCYP2C9MAPTKDM4E | |
| SCHEMBL1261327 | 0.81 | ALDH1A1 (0.55) | ALDH1A1TSHRCYP2C9MAPTKDM4E | |
| SCHEMBL3021950 | 0.79 | ALDH1A1 (0.53) | ALDH1A1TSHRCYP2C9MAPTKDM4E | |
| SCHEMBL238242 | 0.79 | ALDH1A1 (0.53) | ALDH1A1TSHRCYP2C9MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-11065231-B2 | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20190151295-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES | ARVINAS OPERATIONS, INC. | 2019-05-23 | — | — | US | disclosed |
| US-20160166576-A1 | SUBSTITUTED AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES (IRAK-4) | MERCK SHARP & DOHME CORP. (US) | 2016-06-16 | — | — | US | disclosed |
| WO-2015006181-A1 | SUBSTITUTED AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES (IRAK-4) | MERCK SHARP & DOHME CORP. (US) | 2015-01-15 | — | — | WO | disclosed |
| US-8394795-B2 | Pyrazole [3, 4-B] pyridine Raf inhibitors | ARRAY BIOPHARMA INC. (US) | 2013-03-12 | — | — | US | disclosed |
| EP-2265610-B1 | PYRAZOLE [3, 4-B]PYRIDINE RAF INHIBITORS | ARRAY BIOPHARMA INC (US) | 2012-12-12 | — | — | EP | disclosed |
| EP-2470539-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2012-07-04 | — | — | EP | disclosed |
| US-20120157451-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC (US) | 2012-06-21 | — | — | US | disclosed |
| EP-2261301-A1 | Organometallic complexes, organic electroluminescent devices and organic electroluminescent displays | Fujifilm Corporation (JP) | 2010-12-15 | — | — | EP | disclosed |
| US-20100210762-A1 | HETEROCYCLIC COMPOUND, ULTRAVIOLET ABSORBENT AND COMPOSITION CONTAINING THE SAME | FUJIFILM CORPORATION (JP) | 2010-08-19 | — | — | US | disclosed |
| WO-2009111279-A1 | PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | disclosed |
| US-20090121620-A1 | ORGANOMETALLIC COMPLEX, ORGANIC EL ELEMENT AND ORGANIC EL DISPLAY | FUJI PHOTO FILM CO., LTD (JP) | 2009-05-14 | — | — | US | disclosed |
| US-20090121620-A1 | ORGANOMETALLIC COMPLEX, ORGANIC EL ELEMENT AND ORGANIC EL DISPLAY | FUJI PHOTO FILM CO., LTD (JP) | 2009-05-14 | — | — | US | disclosed |
| US-20090121620-A1 | ORGANOMETALLIC COMPLEX, ORGANIC EL ELEMENT AND ORGANIC EL DISPLAY | FUJI PHOTO FILM CO., LTD (JP) | 2009-05-14 | — | — | US | disclosed |
| US-20050244673-A1 | Organometallic complex, organic EL element and organic EL display | FUJITSU LIMITED (JP) | 2005-11-03 | — | — | US | disclosed |
| EP-1550707-A1 | ORGANOMETALLIC COMPLEXES, ORGANIC EL DEVICES, AND ORGANIC EL DISPLAYS | FUJITSU LIMITED (JP) | 2005-07-06 | — | — | EP | disclosed |
| EP-0357783-B1 | SECONDARY NON-LINEAR OPTICAL MATERIAL AND NON-LINEAR OPTICAL ELEMENT PREPARED THEREFROM | SUMITOMO ELECTRIC INDUSTRIES (JP) | 1994-10-26 | — | — | EP | disclosed |
| EP-0357783-A1 | SECONDARY NON-LINEAR OPTICAL MATERIAL AND NON-LINEAR OPTICAL ELEMENT PREPARED THEREFROM | SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) | 1990-03-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151295-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES | IRAK1, IRAK4, IRAK2 | ALDH1A1 2896/4885TSHR 3443/4885CYP2C9 4862/4885 |
| US-20100210762-A1 | HETEROCYCLIC COMPOUND, ULTRAVIOLET ABSORBENT AND COMPOSITION CONTAINING THE SAME | F12, F2, CYP24A1 | ALDH1A1 1492/4885TSHR 972/4885CYP2C9 553/4885 |
| US-20090121620-A1 | ORGANOMETALLIC COMPLEX, ORGANIC EL ELEMENT AND ORGANIC EL DISPLAY | ORC3, RPL29, OR51E2 | ALDH1A1 3392/4885TSHR 3370/4885CYP2C9 2637/4885 |
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | IRAK1, IRAK4, IRAK2 | ALDH1A1 2211/4885TSHR 3456/4885CYP2C9 4868/4885 |
| US-20120157451-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | ALDH1A1 1505/4885TSHR 2501/4885CYP2C9 4040/4885 |
| US-11065231-B2 | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides | IRAK1, IRAK4, IRAK2 | ALDH1A1 2896/4885TSHR 3443/4885CYP2C9 4862/4885 |
| US-20160166576-A1 | SUBSTITUTED AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES (IRAK-4) | IRAK1, IRAK3, IRAK4 | ALDH1A1 2491/4885TSHR 2177/4885CYP2C9 4147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.