Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP4 | P49662 | 1/20 | 0.40 |
| ▸ | CASP5 | P51878 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL923005 | 0.98 | SMN1; SMN2 (0.49) | SMN1; SMN2HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL19924700 | 0.98 | SMN1; SMN2 (0.53) | SMN1; SMN2HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL922909 | 0.82 | KMT2A (0.49) | KDM4EALDH1A1GAAMAPTCRHBP | |
| SCHEMBL922677 | 0.82 | HRH4 (0.50) | HRH4 | |
| Hydrochloric Acid SCHEMBL925122 | 0.81 | KMT2A (0.47) | KDM4EALDH1A1GAAMAPTCRHBP | |
| SCHEMBL1269262 | 0.75 | KDM4E (0.50) | SMN1; SMN2HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL12692666 | 0.69 | ALK (0.48) | HSD17B10KDM4ENPC1ALDH1A1GAA | |
| SCHEMBL15822827 | 0.68 | ALDH1A1 (0.47) | SMN1; SMN2HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL13779832 | 0.67 | HRH4 (0.57) | SMN1; SMN2HSD17B10KDM4EALDH1A1MAPT | |
| SCHEMBL14783337 | 0.66 | KMT2A (0.46) | SMN1; SMN2KDM4EALDH1A1MAPTHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470539-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2012-07-04 | — | — | EP | disclosed |
| US-20120157451-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC (US) | 2012-06-21 | — | — | US | disclosed |
| CN-102482283-A | Raf inhibitor compounds and methods of use thereof | ARRAY BIOPHARMA INC | 2012-05-30 | — | — | CN | disclosed |
| WO-2011025951-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157451-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | SMN1; SMN2 1935/4885HSD17B10 2882/4885KDM4E 3835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.