Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 20/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.79 |
| ▸ | ACHE | P22303 | 1/20 | 0.79 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.79 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16118006 | 0.95 | KCNJ1 (0.90) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL19264178 | 0.94 | KCNJ1 (0.88) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL17925038 | 0.93 | KCNJ1 (0.86) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL14933625 | 0.93 | KCNJ1 (0.86) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL19397993 | 0.93 | KCNJ1 (0.86) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL14933631 | 0.93 | KCNJ1 (1.00) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| Hydrochloric Acid SCHEMBL19244724 | 0.92 | KCNJ1 (0.85) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL14933650 | 0.90 | KCNJ1 (1.00) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL19379385 | 0.90 | KCNJ1 (0.81) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL17697170 | 0.90 | KCNJ1 (0.81) | KCNJ1KCNH2ACHESSTR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773351-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2017-08-23 | — | — | EP | claimed |
| EP-2773351-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2017-08-23 | — | — | EP | disclosed |
| US-9493474-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2016-11-15 | — | — | US | disclosed |
| US-9493474-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2016-11-15 | — | — | US | disclosed |
| US-20140288042-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC | 2014-09-25 | — | — | US | disclosed |
| US-20140288042-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC | 2014-09-25 | — | — | US | disclosed |
| WO-2013066718-A2 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2013-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288042-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | KCNJ2, KCNJ11, KCNK2 | KCNJ1 5/4885KCNH2 6/4885ACHE 4848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.