Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 20/20 | 0.88 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.69 |
| ▸ | ACHE | P22303 | 1/20 | 0.69 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14933602 | 0.94 | KCNJ1 (1.00) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL16118006 | 0.91 | KCNJ1 (0.90) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL17925038 | 0.89 | KCNJ1 (0.86) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL14933625 | 0.89 | KCNJ1 (0.86) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL14933631 | 0.89 | KCNJ1 (1.00) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| Hydrochloric Acid SCHEMBL19244724 | 0.88 | KCNJ1 (0.85) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL19397993 | 0.87 | KCNJ1 (0.86) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL14933650 | 0.87 | KCNJ1 (1.00) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL16075617 | 0.86 | KCNJ1 (0.74) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL19379385 | 0.84 | KCNJ1 (0.81) | KCNJ1KCNH2ACHESSTR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773351-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2017-08-23 | — | — | EP | disclosed |