Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12602969 | 0.85 | BTK (0.46) | BTKALDH1A1 | |
| SCHEMBL1725758 | 0.84 | BTK (0.39) | BTKMAPK14MAP2K1RXFP1 | |
| SCHEMBL10255868 | 0.84 | MAPK14 (0.47) | BTKMAPK14MAP2K1 | |
| SCHEMBL13186833 | 0.82 | BTK (0.34) | BTKMAPK14ALDH1A1CLK2RXFP1 | |
| SCHEMBL21017744 | 0.82 | NPC1 (0.36) | BTKMAPK14ALDH1A1MAP2K1RXFP1 | |
| SCHEMBL24374769 | 0.82 | BTK (0.43) | BTK | |
| SCHEMBL14696131 | 0.81 | HCAR3 (0.47) | BTKRXFP1 | |
| SCHEMBL29741941 | 0.81 | JAK2 (0.38) | BTKALDH1A1 | |
| SCHEMBL14912788 | 0.81 | JAK2 (0.38) | BTKALDH1A1 | |
| SCHEMBL10256657 | 0.81 | BTK (0.38) | BTKCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013067274-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY | GENENTECH, INC. (US) | 2013-05-10 | — | — | WO | disclosed |