Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.76 |
| ▸ | HDAC4 | P56524 | 14/20 | 0.76 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20593509 | 1.00 | HDAC6 (0.76) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL20593540 | 0.91 | HDAC4 (0.71) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL20593259 | 0.90 | HDAC4 (0.69) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL14935042 | 0.90 | HDAC4 (0.69) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL20593602 | 0.90 | HDAC6 (0.80) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL20593556 | 0.88 | HDAC6 (0.64) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL20593515 | 0.87 | HDAC6 (0.64) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL14935014 | 0.87 | HDAC6 (0.71) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL20593440 | 0.87 | HDAC6 (0.69) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL22530800 | 0.87 | HDAC4 (0.66) | HDAC6HDAC4HDAC1HDAC5HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066835-A2 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |