Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.71 |
| ▸ | RAF1 | P04049 | 15/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.48 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.48 |
| ▸ | NQO1 | P15559 | 1/20 | 0.46 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL959013 | 0.93 | MAP2K1 (0.82) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL12917636 | 0.83 | MAP2K1 (1.00) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL960824 | 0.80 | MAP2K1 (0.55) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL16457373 | 0.79 | MAP2K1 (0.62) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL962892 | 0.77 | MAP2K1 (0.58) | MAP2K1RAF1CYP2C9CYP3A4NQO1 | |
| SCHEMBL960075 | 0.74 | MAP2K1 (0.84) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL971525 | 0.73 | MAP2K1 (0.68) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL959279 | 0.73 | MAP2K1 (0.86) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL1494150 | 0.73 | MAP2K1 (0.71) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL958959 | 0.72 | MAP2K1 (0.79) | MAP2K1RAF1CYP2C9CYP3A4BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897792-B2 | Coumarin derivative having antitumor activity | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-03-01 | — | — | US | disclosed |
| US-20100004233-A1 | NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004233-A1 | NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, SULT1A1, SULT1E1 | MAP2K1 3163/4885RAF1 438/4885CYP2C9 448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.