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SULT1A1

Sulfotransferase 1A1 · P50225 · SULT1A1 on Sugi Atlas →

6,618 patent compounds predicted against SULT1A1, 5,793 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1984683 SCHEMBL1984683 0.84 4/20
SCHEMBL1984686 SCHEMBL1984686 0.84 4/20
Pittsburgh Compound B Unlabelled Pittsburgh Compound B Unlabelled (SCHEMBL2055283) 0.82 4/20
SCHEMBL1572293 SCHEMBL1572293 0.72 4/20
SCHEMBL796265 SCHEMBL796265 0.69 4/20
SCHEMBL796259 SCHEMBL796259 0.68 4/20
SCHEMBL2055228 SCHEMBL2055228 0.67 4/20
SCHEMBL2061295 SCHEMBL2061295 0.66 4/20
SCHEMBL2193632 SCHEMBL2193632 0.65 4/20
SCHEMBL796543 SCHEMBL796543 0.64 4/20
SCHEMBL796932 SCHEMBL796932 0.64 4/20
SCHEMBL1994279 SCHEMBL1994279 0.64 4/20
SCHEMBL2062033 SCHEMBL2062033 0.63 4/20
SCHEMBL2055246 SCHEMBL2055246 0.61 4/20
SCHEMBL796258 SCHEMBL796258 0.60 4/20
SCHEMBL796675 SCHEMBL796675 0.60 4/20
SCHEMBL1664230 SCHEMBL1664230 0.60 4/20
SCHEMBL2061130 SCHEMBL2061130 0.59 4/20
SCHEMBL1987582 SCHEMBL1987582 0.59 4/20
SCHEMBL1987584 SCHEMBL1987584 0.59 4/20

Clinical trials — most relevant to SULT1A1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Comparison of Two Different Doses of Paracetamol for Post-Operative Pain Relief PHASE4COMPLETED
Irinotecan Plus S1 Versus S1 in Patients With Previously Treated Advanced Esophageal Cancer: ESWN 01 Trial PHASE3UNKNOWN
Tamoxifen Citrate in Treating Patients With Metastatic or Recurrent Breast Cancer PHASE2COMPLETED
Activity of Regorafenib in Combination With Chemotherapy in Patients With Advanced Biliary Tract Cancer PHASE1/PHASE2COMPLETED
Variability of Sulfotransferase 1A1 Activity in Humans: an Approach to Improve Predictive Drug Response - Part I: Analysis of Intraindividual Variation in Healthy Adults PHASE1COMPLETED
Variability of Sulfotransferase Activity in Humans: an Approach to Improve Predictive Drug Response Part II: Analysis of Interindividual Variation in Hypertensive Patients PHASE1COMPLETED
2-Methoxyestradiol in Treating Patients With Advanced Solid Tumors PHASE1COMPLETED
Bioavailability of Paracetamol, Amoxicillin and Talinolol Before, Immediately and One Year After Gastric Bypass Operation PHASE1COMPLETED
Pharmacokinetics, Metabolism and Analgesic Effects of Flupirtine PHASE1COMPLETED
Atazanavir/Ritonavir and Darunavir/Ritonavir PK Tail Study PHASE1COMPLETED
Pharmacokinetics (PK) Study of Once Daily Darunavir/Ritonavir and Twice and Once Daily Raltegravir in HIV-infected Subjects PHASE1COMPLETED
Abacavir Pharmacokinetic Study in the Absence/Presence of Darunavir/Ritonavir or Raltegravir in HIV-infected Subjects PHASE1COMPLETED
Neoadjuvant Chemoradiotherapy Followed By Surgery in Treating Patients With Limited-Stage Small Cell Lung Cancer PHASE1COMPLETED
Pharmacokinetics of Benzo[a]Pyrene: Impact of Diet EARLY_PHASE1COMPLETED
Contribution of UGT2B17 to the Pharmacokinetics of Diclofenac EARLY_PHASE1RECRUITING
Tamoxifen in Women With Breast Cancer and in Women at High-Risk of Breast Cancer Who Are Receiving Venlafaxine, Citalopram, Escitalopram, Gabapentin, or Sertraline nanCOMPLETED
APAP Hepatotoxicity After Therapeutic Doses nanUNKNOWN
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole nanWITHDRAWN
Genetic Polymorphisms in UGT1A6 and UGT2B7 in Asian Population: Association With Lung Cancer Phenotype nanUNKNOWN
Polycystic Ovary Syndrome in Type 1 Diabetes nanNOT_YET_RECRUITING
Natural History Study to Determine Drug Metabolism Phenotype and Appropriate Germline Source DNA in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant nanRECRUITING
Effects of Genotype on CYP2C9 Drug Interactions nanCOMPLETED
Genetic Trial to Study Diarrhea in Patients With Stage III Colon Cancer Who Are Receiving Chemotherapy nanCOMPLETED
A Pilot Study of Varying Doses of Tamoxifen in the Setting of Genetic Polymorphisms of CYP2D6 nanCOMPLETED
Pharmacogenetics of Anastrozole in Postmenopausal Women With Estrogen Receptor-Positive and/or Progesterone Receptor-Positive Stage I, Stage II, or Stage III Breast Cancer nanCOMPLETED
Dose-response Effect of Alcohol Ingestion on Steroid Profile nanCOMPLETED
Genetic Study of Patients Previously Treated With Flavopiridol on Clinical Trial NCI-97-C-0171C nanCOMPLETED
Studying Urine and Blood Samples in Women With Newly Diagnosed Breast Cancer nanCOMPLETED
The Clinical and Economic Impact of Pharmacogenomic Testing for Tamoxifen Metabolism in Postmenopausal Women Receiving Tamoxifen for Prevention of Recurrent Breast Cancer nanCOMPLETED
Individualized Antiretroviral Therapy nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a SULT1A1 binder may also engage these)

ProteinNameSimilarity
P0DMN0 — 1.000 P0DMN0 →
P52846 — 1.000 P52846 →
Q29476 — 1.000 Q29476 →
P0DMM9 — 1.000 P0DMM9 →
P52840 — 1.000 P52840 →
P50226 — 1.000 P50226 →
P17988 — 0.997 P17988 →
P50227 — 0.994 P50227 →
O46503 — 0.994 O46503 →
Q9WUW9 — 0.992 Q9WUW9 →
O00338 — 0.992 O00338 →
Q9D939 — 0.991 Q9D939 →
Q8JG30 — 0.991 Q8JG30 →
Q9QWG7 — 0.991 Q9QWG7 →
P52841 — 0.989 P52841 →
Q7ZUS4 — 0.989 Q7ZUS4 →
O43704 — 0.989 O43704 →
Q80VR3 — 0.989 Q80VR3 →
P49887 — 0.988 P49887 →
P50234 — 0.988 P50234 →
P52847 — 0.987 P52847 →
G3V9R3 — 0.987 G3V9R3 →
Q7T2V2 — 0.987 Q7T2V2 →
B2RVI8 — 0.987 B2RVI8 →
F1QYJ6 — 0.987 F1QYJ6 →
SULT2A1 Sulfotransferase 2A1 0.987 landscape →
P19217 — 0.987 P19217 →
Q6WG18 — 0.987 Q6WG18 →
Q9WUW8 — 0.987 Q9WUW8 →
A0A2K5X3B6 — 0.987 A0A2K5X3B6 →