Sugi Predict

Sugi Predict / Compounds / SCHEMBL14938754

SCHEMBL14938754

SCHEMBL14938754

COC(=O)C(N)Cc1ccc(C#N)cc1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 4/20 0.48
▸ FAP Q12884 2/20 0.48
▸ DPP8 Q6V1X1 2/20 0.48
▸ DPP9 Q86TI2 2/20 0.48
▸ DPP7 Q9UHL4 2/20 0.48
▸ NLRP3 Q96P20 1/20 0.47
▸ ALDH1A1 P00352 2/20 0.47
▸ TPH1 P17752 1/20 0.46
▸ ANPEP P15144 2/20 0.45
▸ CYP11B1 P15538 2/20 0.44
▸ CYP11B2 P19099 2/20 0.44
▸ LOXL2 Q9Y4K0 1/20 0.43
▸ GPR142 Q7Z601 1/20 0.43
▸ SAE1 Q9UBE0 1/20 0.43
▸ UBA2 Q9UBT2 1/20 0.43
▸ MAOB P27338 1/20 0.42
▸ LTA4H P09960 1/20 0.42
▸ MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5569674 1.00 DPP4 (0.48) DPP4FAPDPP8DPP9DPP7
SCHEMBL16060347 1.00 DPP4 (0.48) DPP4FAPDPP8DPP9DPP7
Hydrochloric Acid SCHEMBL16060346 0.98 ALDH1A1 (0.49) DPP4FAPDPP8DPP9DPP7
Hydrochloric Acid SCHEMBL5569670 0.98 ALDH1A1 (0.49) DPP4FAPDPP8DPP9DPP7
Hydrochloric Acid SCHEMBL5569672 0.98 ALDH1A1 (0.49) DPP4FAPDPP8DPP9DPP7
SCHEMBL539320 0.96 DPP4 (0.53) DPP4FAPDPP8DPP9DPP7
SCHEMBL539309 0.96 DPP4 (0.53) DPP4FAPDPP8DPP9DPP7
SCHEMBL539319 0.96 DPP4 (0.53) DPP4FAPDPP8DPP9DPP7
Hydrochloric Acid SCHEMBL539308 0.94 DPP4 (0.52) DPP4FAPDPP8DPP9DPP7
Hydrochloric Acid SCHEMBL539344 0.94 DPP4 (0.52) DPP4FAPDPP8DPP9DPP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110869352-B Chemical compound 诺瑟拉有限公司 2023-11-28 — — CN disclosed
EP-3008056-B1 NOVEL GLP-1 RECEPTOR MODULATORS CELGENE INT II SARL (CH) 2020-12-09 — — EP disclosed
EP-2791112-B1 CARBOXYLIC ACID DERIVATIVES COMPRISING FOUR CYCLES ACTING AS GLP-1 RECEPTOR MODULATORS FOR THERAPY OF DISEASES SUCH AS DIABETES CELGENE INT II SÀRL (CH) 2020-09-23 — — EP disclosed
EP-3230276-B1 GLP-1 RECEPTOR MODULATORS CELGENE INT II SARL (CH) 2020-09-02 — — EP disclosed
CN-110869352-A Chemical compound 诺瑟拉有限公司 2020-03-06 — — CN disclosed
EP-2776411-B1 MODULATORS OF C3A RECEPTORS UNIV QUEENSLAND (AU) 2019-06-26 — — EP disclosed
US-10259823-B2 GLP-1 receptor modulators CELGENE INTERNATIONAL II SÀRL (CH) 2019-04-16 — — US disclosed
US-10034886-B2 GLP-1 receptor modulators CELGENE INTERNATIONAL II SÀRL (CH) 2018-07-31 — — US disclosed
US-20180021346-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2018-01-25 — — US disclosed
US-20170313717-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2017-11-02 — — US disclosed
US-20150038416-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2015-02-05 — — US disclosed
US-20150011527-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS LLC 2015-01-08 — — US disclosed
WO-2014201172-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS, INC. (US) 2014-12-18 — — WO disclosed
EP-2791112-A2 CARBOXYLIC ACID DERIVATIVES COMPRISING FOUR CYCLES ACTING AS GLP-1 RECEPTOR MODULATORS FOR THERAPY OF DISEASES SUCH AS DIABETES Receptos, Inc. (US) 2014-10-22 — — EP disclosed
US-20140302069-A1 MODULATORS OF C3A RECEPTORS THE UNIVERSITY OF QUEENSLAND (AU) 2014-10-09 — — US disclosed
EP-2776411-A1 MODULATORS OF C3A RECEPTORS The University of Queensland (AU) 2014-09-17 — — EP disclosed
US-8778923-B2 GLP-1 receptor modulators RECEPTOS, INC. (US) 2014-07-15 — — US disclosed
US-20130178420-A1 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS, INC. (US) 2013-07-11 — — US disclosed
WO-2013090454-A2 NOVEL GLP-1 RECEPTOR MODULATORS RECEPTOS, INC. (US) 2013-06-20 — — WO disclosed
WO-2013067578-A1 MODULATORS OF C3A RECEPTORS THE UNIVERSITY OF QUEENSLAND (AU) 2013-05-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170313717-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R DPP4 54/4885FAP 2274/4885DPP8 76/4885
US-20140302069-A1 MODULATORS OF C3A RECEPTORS C3AR1, C5AR2, C5AR1 DPP4 303/4885FAP 1996/4885DPP8 371/4885
US-20180021346-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R DPP4 54/4885FAP 2274/4885DPP8 76/4885
US-20130178420-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R DPP4 50/4885FAP 2458/4885DPP8 89/4885
US-20150038416-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R DPP4 50/4885FAP 2458/4885DPP8 89/4885
US-10034886-B2 GLP-1 receptor modulators GLP1R, GIPR, GCGR DPP4 51/4885FAP 2251/4885DPP8 84/4885
US-10259823-B2 GLP-1 receptor modulators GLP1R, GIPR, GCGR DPP4 51/4885FAP 2251/4885DPP8 84/4885
US-20150011527-A1 NOVEL GLP-1 RECEPTOR MODULATORS GLP1R, GIPR, NPY1R DPP4 54/4885FAP 2274/4885DPP8 76/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.