SCHEMBL14938972

SCHEMBL14938972

O=C1c2ccccc2C(=O)C1(Br)c1cccc(Cl)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.41
ALDH1A1 P00352 8/20 0.41
ALOX12 P18054 4/20 0.41
L3MBTL1 Q9Y468 4/20 0.41
TSHR P16473 2/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA7 P43166 2/20 0.41
RECQL P46063 2/20 0.41
CA9 Q16790 2/20 0.41
EHMT2 Q96KQ7 2/20 0.41
MAPK1 P28482 2/20 0.41
CASP1 P29466 1/20 0.41
BACE1 P56817 1/20 0.41
S100A4 P26447 1/20 0.39
MAPT P10636 7/20 0.37
TDP2 O95551 4/20 0.37
KDM4E B2RXH2 3/20 0.37
APAF1 O14727 3/20 0.37
NSD2 O96028 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14939171 0.80 CYP2D6 (0.42) CYP2D6ALDH1A1ALOX12L3MBTL1TSHR
SCHEMBL14939120 0.79 CYP2D6 (0.45) CYP2D6ALDH1A1ALOX12L3MBTL1TSHR
SCHEMBL14939567 0.75 CYP2D6 (0.41) CYP2D6ALDH1A1ALOX12L3MBTL1TSHR
SCHEMBL14939982 0.75 CYP2D6 (0.45) CYP2D6ALDH1A1ALOX12L3MBTL1TSHR
SCHEMBL14939223 0.75 CYP2D6 (0.53) CYP2D6ALDH1A1ALOX12L3MBTL1TSHR
SCHEMBL14939206 0.72 ALDH1A1 (0.45) CYP2D6ALDH1A1ALOX12L3MBTL1TSHR
SCHEMBL14940197 0.71 NPC1 (0.45) CYP2D6ALDH1A1ALOX12L3MBTL1TSHR
SCHEMBL14940040 0.71 CYP2D6 (0.45) CYP2D6ALDH1A1ALOX12L3MBTL1TSHR
SCHEMBL14939640 0.69 KMT2A (0.41) CYP2D6ALDH1A1ALOX12L3MBTL1TSHR
SCHEMBL14940123 0.68 ALDH1A1 (0.47) CYP2D6ALDH1A1ALOX12L3MBTL1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013068785-A1 INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS ACTELION PHARMACEUTICALS LTD (CH) 2013-05-16 WO disclosed