Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | TP53 | P04637 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | HTR2B | P41595 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10623023 | 0.80 | MAPT (0.64) | MAPTTP53MAPK1LMNACYP3A4 | |
| SCHEMBL14940489 | 0.80 | MAPT (0.64) | MAPTTP53MAPK1LMNACYP3A4 | |
| SCHEMBL3500770 | 0.80 | TP53 (0.64) | MAPTTP53MAPK1LMNACYP3A4 | |
| SCHEMBL14939430 | 0.79 | MAPT (0.62) | MAPTTP53MAPK1LMNACYP3A4 | |
| Phenindione SCHEMBL33831 | 0.78 | MAPT (1.00) | MAPTTP53MAPK1LMNACYP3A4 | |
| Phenindione SCHEMBL29388073 | 0.78 | MAPT (1.00) | MAPTTP53MAPK1LMNACYP3A4 | |
| SCHEMBL10559114 | 0.76 | MAPT (0.95) | MAPTTP53MAPK1LMNACYP3A4 | |
| Phenindione SCHEMBL1443973 | 0.76 | MAPT (0.95) | MAPTTP53MAPK1LMNACYP3A4 | |
| Phenindione SCHEMBL6827577 | 0.76 | MAPT (0.95) | MAPTTP53MAPK1LMNACYP3A4 | |
| SCHEMBL14939639 | 0.76 | MAPT (0.58) | MAPTTP53MAPK1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |