Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939190 | 0.88 | MAPT (0.57) | MAPTNPSR1DCUN1D1HTR7DRD2 | |
| SCHEMBL14940320 | 0.87 | NPSR1 (0.72) | MAPTNPSR1DCUN1D1DRD4OPRL1 | |
| SCHEMBL14939967 | 0.86 | NPSR1 (0.57) | MAPTNPSR1SIGMAR1TP53KDM4E | |
| SCHEMBL14939885 | 0.86 | NPSR1 (0.59) | MAPTNPSR1DRD2DRD4DRD3 | |
| SCHEMBL14940042 | 0.85 | MAPT (0.54) | MAPTNPSR1HTR7CCR2TP53 | |
| SCHEMBL14940377 | 0.85 | NPSR1 (0.74) | MAPTNPSR1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL14940010 | 0.84 | NPSR1 (0.57) | MAPTNPSR1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL14939107 | 0.84 | NPSR1 (0.57) | MAPTNPSR1HTR7SIGMAR1TP53 | |
| SCHEMBL14939266 | 0.84 | MAPT (0.55) | MAPTNPSR1DCUN1D1HTR7DRD2 | |
| SCHEMBL14940356 | 0.84 | NPSR1 (0.54) | MAPTNPSR1SIGMAR1TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |