Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939868 | 0.92 | NPSR1 (0.52) | MAPTNPSR1HTR7LMNATP53 | |
| SCHEMBL14940024 | 0.91 | MAPT (0.50) | MAPTNPSR1HTR7LMNATP53 | |
| SCHEMBL14939311 | 0.91 | NPSR1 (0.51) | MAPTNPSR1HTR7LMNATP53 | |
| SCHEMBL14939938 | 0.89 | MAPT (0.51) | MAPTNPSR1HTR7LMNADRD2 | |
| SCHEMBL14939603 | 0.89 | NPSR1 (0.49) | MAPTNPSR1HTR7LMNATP53 | |
| SCHEMBL14940181 | 0.88 | NPSR1 (0.67) | MAPTNPSR1HTR7LMNADRD2 | |
| SCHEMBL14939507 | 0.85 | MAPT (0.48) | MAPTNPSR1HTR7LMNATP53 | |
| SCHEMBL14940061 | 0.84 | NPSR1 (0.57) | MAPTNPSR1HTR7LMNATP53 | |
| SCHEMBL14939809 | 0.83 | NPSR1 (0.51) | MAPTNPSR1HTR7LMNATP53 | |
| SCHEMBL14939244 | 0.83 | NPSR1 (0.71) | MAPTNPSR1HTR7LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |