Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | FGB | P02675 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11807554 | 0.86 | KDM4E (0.53) | RAB9AGAANPSR1MAPTSMN1; SMN2 | |
| SCHEMBL11673444 | 0.82 | CA12 (0.50) | RAB9AGAAMAPTSMN1; SMN2HPGD | |
| SCHEMBL10494831 | 0.74 | MEN1 (0.47) | RAB9ANPSR1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL9145942 | 0.74 | CYP19A1 (0.57) | MAPTPTGS2MEN1KMT2ACYP19A1 | |
| SCHEMBL15874610 | 0.74 | CYP19A1 (0.57) | MAPTPTGS2MEN1KMT2ACYP19A1 | |
| SCHEMBL29475765 | 0.74 | CYP19A1 (0.47) | RAB9AGAANPSR1MAPTTP53 | |
| SCHEMBL11807034 | 0.74 | KMT2A (0.53) | RAB9AGAAMAPTSMN1; SMN2TP53 | |
| SCHEMBL11808574 | 0.73 | MAPT (0.57) | RAB9AGAANPSR1MAPTSMN1; SMN2 | |
| SCHEMBL11803990 | 0.71 | TP53 (0.47) | RAB9AGAAMAPTSMN1; SMN2TP53 | |
| SCHEMBL14938865 | 0.70 | MAPT (0.56) | RAB9AGAANPSR1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |