Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14940489 | 0.80 | MAPT (0.64) | MAPTTP53MAPK1LMNACYP1A2 | |
| SCHEMBL11803870 | 0.78 | TOP1 (0.45) | MAPTMAPK1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL10623023 | 0.76 | MAPT (0.64) | MAPTTP53MAPK1LMNACYP1A2 | |
| SCHEMBL3500770 | 0.76 | TP53 (0.64) | MAPTTP53MAPK1LMNACYP1A2 | |
| SCHEMBL10833433 | 0.76 | RAB9A (0.69) | MAPTTP53MAPK1LMNACYP1A2 | |
| SCHEMBL11805856 | 0.76 | TOP1 (0.43) | MAPTMAPK1LMNACYP1A2CYP3A4 | |
| SCHEMBL14939639 | 0.75 | MAPT (0.58) | MAPTTP53MAPK1LMNACYP1A2 | |
| SCHEMBL14939009 | 0.75 | MAPT (0.62) | MAPTTP53MAPK1LMNACYP1A2 | |
| SCHEMBL14939430 | 0.75 | MAPT (0.62) | MAPTTP53MAPK1LMNACYP1A2 | |
| Phenindione SCHEMBL29388073 | 0.74 | MAPT (1.00) | MAPTTP53MAPK1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |