Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.77 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939372 | 0.91 | NPSR1 (0.63) | NPSR1MAPTMMP2MMP9POLB | |
| SCHEMBL14939257 | 0.88 | NPSR1 (0.60) | NPSR1MAPTSIGMAR1 | |
| SCHEMBL14939318 | 0.88 | NPSR1 (0.60) | NPSR1POLBKDM4ETDP1 | |
| SCHEMBL14939617 | 0.87 | NPSR1 (1.00) | NPSR1MAPTMMP2MMP9LMNA | |
| SCHEMBL14939475 | 0.87 | NPSR1 (0.58) | NPSR1MAPTKDM4ELMNAFAAH | |
| SCHEMBL14939425 | 0.87 | NPSR1 (0.79) | NPSR1MAPTMMP2MMP9KDM4E | |
| SCHEMBL14940010 | 0.86 | NPSR1 (0.57) | NPSR1MAPTKDM4ELMNATDP1 | |
| SCHEMBL14939933 | 0.86 | NPSR1 (0.77) | NPSR1MAPTMMP2MMP9POLB | |
| SCHEMBL14939709 | 0.86 | NPSR1 (0.77) | NPSR1MAPTMMP2MMP9LMNA | |
| SCHEMBL14939432 | 0.85 | NPSR1 (0.68) | NPSR1MAPTMMP2MMP9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | claimed |
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |