Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14939577 | 0.91 | NPSR1 (0.52) | TP53NPSR1MAPTLMNAHTR7 | |
| SCHEMBL14939514 | 0.90 | NPSR1 (0.47) | TP53NPSR1MAPTLMNAGRIN2B | |
| SCHEMBL14939110 | 0.90 | NPSR1 (0.55) | TP53NPSR1MAPTLMNAGRIN2B | |
| SCHEMBL14939200 | 0.88 | NPSR1 (0.53) | TP53NPSR1MAPTLMNAHTR7 | |
| SCHEMBL14939486 | 0.88 | TP53 (0.52) | TP53NPSR1MAPTLMNAGRIN2B | |
| SCHEMBL14939106 | 0.88 | NPSR1 (0.64) | TP53NPSR1MAPTLMNAGRIN2B | |
| SCHEMBL14939761 | 0.87 | NPSR1 (0.61) | TP53NPSR1MAPTSIGMAR1DRD2 | |
| SCHEMBL14939396 | 0.86 | NPSR1 (0.51) | TP53NPSR1MAPTLMNAGRIN2B | |
| SCHEMBL14940165 | 0.86 | NPSR1 (0.51) | TP53NPSR1MAPTLMNAGRIN2B | |
| SCHEMBL14940141 | 0.86 | NPSR1 (0.54) | TP53NPSR1MAPTLMNAGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068785-A1 | INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-05-16 | — | — | WO | disclosed |